Novel Biomarkers of Endothelial Dysfunction and Angiogenesis Alterations in PCS and ME/CFS

Prof. Seifert's presentation highlighted new research on biomarkers for endothelial dysfunction and angiogenesis disorders in PCS and ME/CFS. These biomarkers are sought in serum and blood cells to potentially explain the processes leading to vascular inflammation and endothelial dysfunction. For example, autoantibodies against endothelial cells have been shown to be elevated in patients with PCS that fulfil diagnostic criteria for ME/CFS. This could be related to the hypoperfusion and micro-clots seen in PCS. Different processes may occur in patients with PCS with ME/CFS compared to patients with PCS without ME/CFS. Compensatory new vascular branches were formed in PCS, but this did not occur in PCS patients with ME/CFS. This process could help determine which patients recover from PCS and which have persistent ME/CFS.