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Association between serum antibodies and exercise intolerance and muscular/neuronal fatigue in ME/CFS

About

Status:
Ongoing
Principal investigator:
Country:
Latvia
Study start:
Not available
Completion (planned):
Not available
Last update:
2023-11-30

 

Research types:
Basic research
Research areas:
Infections, Immunological dysfunction, Nutritional and metabolic system disorder
Interventions:
Not applicable
Priv. Sector Partner:
Not available
Sponsors:

Project description

The study led by PD Dr. Bhupesh Kumar Prusty at the Institute of Virology and Immunobiology at the Julius Maximilian University of Würzburg examines the connection between viral infections (particularly HHV-6, HHV-7 and EBV), autoimmunity and mitochondria in the development and progression of ME/CFS. The researchers use a novel method called Targeted Immunoglobulin Associated Proteomics (TIgAP) to identify proteins that may be targets for ME/CFS-specific antibodies.

The main aim of this study is to apply the immunoglobulin fractions from ME/CFS patients and healthy controls (n = 10 each) to different primary cell types and to isolate proteins that are specifically related to the IgG fractions of ME/CFS Patients interact. These proteins will then be identified using mass spectrometry and their interactions with IgG will be validated in further studies.

(Description adapted from project website: see link above)

Patient cohort

Post-infectious ME/CFS compared with healthy controls.

Patients enrolled: 20

Age group: Not available

Research areas (6)
Research types (2)
Research networks (0)
Working groups (1)
People (1)
Publications (0)
Organisations (1)

Research areas

Mitochondrial dysfunction
Description:
Mitochondrial diseases are conditions caused by abnormal function of the mitochondira. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes. (Description adapted from: ...
Research projects:
5
Publications:
6
Immunological dysfunction
Description:
Immune system is the body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. Diseases of the immune system are disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-m...
Research projects:
17
Publications:
39