An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Abstract

There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In  this paper we deduce the pathomechanisms resulting in central nervous pathology  and the myriad of neurocognitive symptoms. We outline tentative mechanisms of  impaired cerebral blood flow, increase in intracranial pressure and central  adrenergic hyperactivity and how they can well explain the key symptoms of  cognitive impairment, brain fog, headache, hypersensitivity, sleep disturbances  and dysautonomia.