Human deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase)

Description

Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) catalyses the magnesium-dependent hydrolysis of dUTP to dUMP and pyrophosphate, providing the substrate for methylation of uracil by thymidylate synthase and preventing accidental incorporation of uracil into DNA by DNA-polymerase. (Description adapted from https://www.sciencedirect.com/science/article/pii/S0014579302031587).