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Research areas

Immune system dysfunction

Description

Immune system is the body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. Diseases of the immune system are disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both. Description adapted from https://www.ncbi.nlm.nih.gov/mesh/68007154 and https://www.ncbi.nlm.nih.gov/mesh/68007107.

Research projects
48
Research types
18
Research networks
9
Working groups
39
People
147
Publications
75
Event items
18

Research projects

Analysing Antibody Responses against EBV-derived Antigens in ME/CFS
Project status:
Completed
Country:
Poland, UK, Germany
Principal investigator:
Carmen Scheibenbogen, Nuno Sepúlveda
Organisations:
Charité – University Medicine Berlin, Warsaw University of Technology, London School of Hygiene & Tropical Medicine (LSHTM)
Research period:
2020-10
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Antibody catching
Project status:
Completed
Country:
Germany
Principal investigator:
André Dallmann
Organisations:
Humboldt University of Berlin
Research period:
Not available
Research types:
Clinical research
Research areas:
Immune system dysfunction
Antibody repertoires against microbiota as biomarkers for ME/CFS (CFSmicroAbs)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
A.P. (Alexandra) Zhernakova
Organisations:
University of Groningen
Research period:
2023-09
to 2027-09
Research types:
Epidemiological research
Research areas:
Infections, Immune system dysfunction, Digestive system dysfunction, General
Autoantibody-induced Transcriptome and Proteome as Biomarkers
Project status:
Ongoing
Country:
Germany
Principal investigator:
Gabriela Riemekasten
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Luebeck
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Autoimmunity Risk Variants in the PTPN22 and CTLA4 Genes are Associated with Infectious Onset of ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Sophie Steiner
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction, Genetic risk factors, General
Autoimmunity as a cause of ME/CFS symptoms (AutonoME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Jeroen den Dunnen
Organisations:
Amsterdam University Medical Center (Amsterdam UMC)
Research period:
2023-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Biosamples, GPCR-Autoantibodies, Data Management and Bioinformatics
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Luebeck, University Hospital rechts der Isar (MRI TUM), Charité – University Medicine Berlin, Max Delbrück Center (MDC), Technical University of Munich (TUM)
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, General
Blood cell physics
Project status:
Completed
Country:
Germany
Principal investigator:
Jochen Guck
Organisations:
Max Planck Institute for the Science of Light
Research period:
Not available
Research types:
Clinical research
Research areas:
Hemic and lymphatic system dysfunction, Immune system dysfunction, Cardiovascular system dysfunction
Chronic Fatigue Syndrome and Immunedeficiencies
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
2019-03
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinic and granulocytes
Project status:
Ongoing
Country:
Germany
Principal investigator:
Alexander Dejaco
Organisations:
University Clinic Regensburg
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Cardiovascular system dysfunction, General
Clinic, HDL proteome, and AI
Project status:
Ongoing
Country:
Germany
Principal investigator:
Elisabeth Schieffer
Organisations:
University Clinic Giessen and Marburg
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Clinical and immunological phenotyping and analysis of EBV autoantigens and autoantigens
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical and immunological phenotyping, analysis of autoantigens and T and B cell communication
Project status:
Ongoing
Country:
Germany
Principal investigator:
Birgit Sawitzki
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical characterisation for biomarker discovery
Project status:
Ongoing
Country:
Germany
Principal investigator:
Helena Radbruch
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Converging neurobiological and immune pathways in ME/CFS and post-infectious fatigue syndromes (PIFS)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Ruud Raijmakers
Organisations:
Radboud University Medical Centre (Radboud UMC)
Research period:
2023-01
to 2027-12
Research types:
Epidemiological research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Endocrine system dysfunction, General
Cyclophosphamide in ME/​CFS (CycloME)
Project status:
Completed
Country:
Norway
Principal investigator:
Øystein Fluge
Organisations:
Haukeland University Hospital
Research period:
2015-03
to 2019-12
Research types:
Clinical research
Research areas:
Immune system dysfunction
Deciphering systemic and mucosal antibody repertoires against the microbiota in ME/CFS and PCC (CFSabs)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Thomas Vogl
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
Research types:
Basic research
Research areas:
Immune system dysfunction, Digestive system dysfunction
Defective Energy Metabolism in ME/CFS
Project status:
Completed
Country:
Norway
Principal investigator:
Øystein Fluge, Olav Mella, Karl Johan Tronstad
Organisations:
Haukeland University Hospital, University of Bergen
Research period:
2017-07
to 2021-02
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Development and analysis of a SARS-CoV-2-induced golden hamster animal model for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Michael Muehlebach
Organisations:
Paul-Ehrlich-Institute (PEI)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Development and analysis of a SARS-CoV-2-induced mouse model for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Gregor Ebert
Organisations:
Helmholtz Munich
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Development of Diagnostic Tests to Detect Autoantibodies in CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
EBV, SARS-CoV-2, HSV Mimicry Epitopes and Autoantibodies
Project status:
Ongoing
Country:
Germany
Principal investigator:
Franziska Sotzny
Organisations:
University Hospital rechts der Isar (MRI TUM), Charité – University Medicine Berlin, Technical University of Munich (TUM), Helmholtz Munich
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, General
Establishing Immunological Assays for the Diagnostics of ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Annick Fehrer
Organisations:
University Clinic Bonn, Charité – University Medicine Berlin, German Center for Neurodegenerative Diseases (DZNE)
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
Evaluation of the link between auto-immunity and derangements in immune cell metabolism and function in ME/CFS (EnergiseME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Niels Eijkelkamp
Organisations:
University Medical Centre Utrecht (UMC Utrecht)
Research period:
2023-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Exploring the Glycome: Identifying Glycosylation-Related Biomarkers for severity stratification in Chronic Fatigue Syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Davide Ret
Organisations:
Medical University of Vienna, Medical University of Graz, Technical University of Vienna
Research period:
2025-01
to 2025-12
Research types:
Basic research
Research areas:
Immune system dysfunction
Functional autoantibodies against G-protein-coupled receptors in patients with ME/CFS (FAME)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Immune system dysfunction
Genetic studies in ME/CFS to investigate the potential involvement of the immune system and reveal biomarker
Project status:
Completed
Country:
Norway
Principal investigator:
Benedicte Alexandra Lie
Organisations:
Haukeland University Hospital, Oslo University Hospital
Research period:
2017-01
to 2021-01
Research types:
Basic research
Research areas:
Immune system dysfunction, Genetic risk factors
Healthy Control Population für PAIS-ME/CFS (HelP)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2025-01
to 2029-12
Research types:
Epidemiological research
Research areas:
Hemic and lymphatic system dysfunction, Immune system dysfunction, Nervous system dysfunction, Cardiovascular system dysfunction
Immune Aberrations in Post-Infectious ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anna Aschenbrenner
Organisations:
University Clinic Bonn, Charité – University Medicine Berlin, German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Immune profiling and blood morphology analyses
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christian Puta
Organisations:
University Clinic Jena, Friedrich Schiller University Jena
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction, Nervous system dysfunction
Immunoadsorption in Patients With Chronic Fatigue Syndrome Including Patients With Post-COVID-19 CFS (IA-PACS-CFS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Harald Pruess
Organisations:
Charité – University Medicine Berlin, German Center for Neurodegenerative Diseases (DZNE)
Research period:
2023-10
to 2025-02
Research types:
Clinical research
Research areas:
Immune system dysfunction
Immunoadsorption vs Sham Treatment in Post-COVID-19 Patients With Chronic Fatigue Syndrome (EXTINCT post COVID)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Vega Goedecke
Organisations:
Hannover Medical School (MHH)
Research period:
2023-07
to 2025-06
Research types:
Clinical research
Research areas:
Immune system dysfunction
Insights into immune cell infiltration and mast cell activation in post-exertional malaise in post-COVID
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Rob Wust
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam)
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction
Integrative data analyses of human and animal model samples for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Volker Bruns
Organisations:
Fraunhofer Institute for Integrated Circuits (IIS)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Integrative transcriptome analyses of human and animal model samples for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Emanuel Wyler
Organisations:
Max Delbrück Center (MDC)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) (PoCoVIT)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christiana Franke
Organisations:
Charité – University Medicine Berlin
Research period:
2023-10
to 2025-03
Research types:
Clinical research
Research areas:
Immune system dysfunction, Nervous system dysfunction
Mitochondrial Dysfunction and Metabolic Changes
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Molecular immunological characterisation & multimodal-multicenter intersectoral care for ME/CFS in children and adolescents in Baden-Wuerttemberg (MOVE-ME/CFS-BW)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Thorsten Langer
Organisations:
University Clinic Freiburg
Research period:
2025-03
to not available
Research types:
Epidemiological research
Research areas:
Immune system dysfunction, General
Observational Study of the Effect of Immunoadsorption (IA) in Patients < 18 Years of Age with ME/CFS with Evidence of Autoantibodies (BIAKI)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Wolfgang Ries
Organisations:
DIAKO Hospital
Research period:
2023-11
to 2025-11
Research types:
Clinical research
Research areas:
Immune system dysfunction
Plasma cell targeting using the anti-CD38 antibody daratumumab in patients with ME/CFS – a randomized, placebo-controlled and double-blind phase II study
Project status:
Ongoing
Country:
Norway
Principal investigator:
Øystein Fluge
Organisations:
Haukeland University Hospital
Research period:
2025-06
to 2026-12
Research types:
Clinical research
Research areas:
Immune system dysfunction
Prospective, exploratory, randomized, controlled, double-blind, phase IIa clinical trial in a cross-over design to evaluate the safety and tolerability and potential clinical effects of BC007 in patients with post-COVID syndrome
Project status:
Completed
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
2023-10
to 2024-09
Research types:
Clinical research
Research areas:
Immune system dysfunction
Raman spectroscopic signatures of blood cells
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anuradha Ramoji
Organisations:
Leibniz Institute of Photonic Technology
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction
Relevance of Raman spectroscopic signatures from blood cells in ME/CFS diagnostics
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anuradha Ramoji
Organisations:
Leibniz Institute of Photonic Technology
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction
Repeat Immunoadsorption Post Covid ME/​CFS (RIA)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2022-08
to 2025-01
Research types:
Clinical research
Research areas:
Immune system dysfunction
The impact of mast cell activation on epithelial and endothelial barrier dysregulation in post-infectious ME/CFS (DegranulateME)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
FH Joanneum University of Applied Sciences, Medical University of Vienna
Research period:
2025-01
to 2025-12
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, Nutritional and metabolic system dysfunction, General
The molecular immune signature in ME/CFS as stratification tool for future personalized treatment (IMMUNESTRATIFY)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Willem A. Dik, Marjan Versnel
Organisations:
Erasmus Medical Center (Erasmus MC), Erasmus University Rotterdam
Research period:
2023-01
to 2027-12
Research types:
Basic research
Research areas:
Immune system dysfunction
Treatment with daratumumab injections in moderate to severe ME/CFS
Project status:
Completed
Country:
Norway
Principal investigator:
Øystein Fluge, Olav Mella
Organisations:
Haukeland University Hospital
Research period:
2022-04
to not available
Research types:
Clinical research
Research areas:
Immune system dysfunction
unCOVer Erlangen - ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
Not available
Research types:
Clinical research
Research areas:
Immune system dysfunction