ME/CFS Research Foundation Logo
Research types

Basic research - Applied

Description

Basic medical research in which animal experiments, cell studies, biochemical, genetic and physiological investigations, and studies on the properties of drugs and materials are applied to investigate the effects on a dependent variable. Description adapted from: https://www.aerzteblatt.de/int/archive/article/64227.

​

Research projects
50
Research areas
55
Research networks
7
Working groups
36
People
106
Publications
19
Event items
3

Research projects

Autoimmunity as a cause of ME/CFS symptoms (AutonoME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Jeroen den Dunnen
Organisations:
Amsterdam University Medical Center (Amsterdam UMC)
Research period:
2023-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Development and analysis of a SARS-CoV-2-induced golden hamster animal model for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Michael Muehlebach
Organisations:
Paul-Ehrlich-Institute (PEI)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Development and analysis of a SARS-CoV-2-induced mouse model for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Gregor Ebert
Organisations:
Helmholtz Munich
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Evaluation of the link between auto-immunity and derangements in immune cell metabolism and function in ME/CFS (EnergiseME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Niels Eijkelkamp
Organisations:
University Medical Centre Utrecht (UMC Utrecht)
Research period:
2023-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Altered Endothelial Dysfunction‐related miRs in Plasma from ME/CFS Patients
Project status:
Completed
Country:
Austria
Principal investigator:
Francisco Westermeier
Organisations:
FH Joanneum University of Applied Sciences, Warsaw University of Technology
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Analysing Antibody Responses against EBV-derived Antigens in ME/CFS
Project status:
Completed
Country:
Poland, UK, Germany
Principal investigator:
Carmen Scheibenbogen, Nuno Sepúlveda
Organisations:
Charité – University Medicine Berlin, Warsaw University of Technology
Research period:
2020-10
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Association Between EBV Reactivation and Development of Long-COVID Fatigue
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
Not available
Research types:
Basic research
Research areas:
Infections
Biosamples, GPCR-Autoantibodies, Data Management and Bioinformatics
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Luebeck, Charité – University Medicine Berlin, University Hospital rechts der Isar (MRI TUM), Max Delbrück Center (MDC), Technical University of Munich (TUM)
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, General
Chronic Fatigue Syndrome and Immunedeficiencies
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
2019-03
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Deciphering systemic and mucosal antibody repertoires against the microbiota in ME/CFS and PCC (CFSabs)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Thomas Vogl
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
Research types:
Basic research
Research areas:
Immune system dysfunction, Digestive system dysfunction
Decreased NO Production in Endothelial Cells Exposed to Plasma from ME/CFS Patients
Project status:
Completed
Country:
Austria
Principal investigator:
Jennifer Blauensteiner
Organisations:
FH Joanneum University of Applied Sciences
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
EBV, SARS-CoV-2, HSV Mimicry Epitopes and Autoantibodies
Project status:
Ongoing
Country:
Germany
Principal investigator:
Franziska Sotzny
Organisations:
University Hospital rechts der Isar (MRI TUM), Charité – University Medicine Berlin, Technical University of Munich (TUM), Helmholtz Munich
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, General
Endothelial dysfunction in post-infection fatigue syndromes
Project status:
Ongoing
Country:
Austria, Germany
Principal investigator:
Francisco Westermeier
Organisations:
Charité – University Medicine Berlin, FH Joanneum University of Applied Sciences, Medical University of Vienna, Warsaw University of Technology
Research period:
2024-07
to 2027-06
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Exploring the Glycome: Identifying Glycosylation-Related Biomarkers for severity stratification in Chronic Fatigue Syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Davide Ret
Organisations:
Medical University of Vienna, Medical University of Graz, Technical University of Vienna
Research period:
2025-01
to 2025-12
Research types:
Basic research
Research areas:
Immune system dysfunction
HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS
Project status:
Completed
Country:
Latvia, Germany
Principal investigator:
Bhupesh K. Prusty
Organisations:
Charité – University Medicine Berlin, University Clinic Erlangen, University of Wuerzburg, University of California San Diego, Riga Stradins University
Research period:
Not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system dysfunction, General
Immune Aberrations in Post-Infectious ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anna Aschenbrenner
Organisations:
Charité – University Medicine Berlin, University Clinic Bonn, German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Infectious Triggers and Mitochondrial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2021-08
to not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system dysfunction
Integrative data analyses of human and animal model samples for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Volker Bruns
Organisations:
Fraunhofer Institute for Integrated Circuits (IIS)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Investigation of PEM and ME/CFS-associated changes in tryptophan metabolism at the host and microbiome level
Project status:
Ongoing
Country:
Germany
Principal investigator:
Silvio Waschina
Organisations:
Kiel University (CAU)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Nutritional and metabolic system dysfunction, Digestive system dysfunction
ME/CFS Biobank Austria
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
2023-09
to not available
Research types:
Basic research
Research areas:
General
Mitochondrial Dysfunction and Metabolic Changes
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Raman spectroscopic signatures of blood cells
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anuradha Ramoji
Organisations:
Leibniz Institute of Photonic Technology
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction
Understanding Potential Infectious Triggers and Mitochondrial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2025-01
to not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system dysfunction
Unraveling Endothelial Function in ME/CFS
Project status:
Ongoing
Country:
Austria
Principal investigator:
Francisco Westermeier
Organisations:
FH Joanneum University of Applied Sciences, Warsaw University of Technology, Medical University of Graz
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Autoantibody-induced Transcriptome and Proteome as Biomarkers
Project status:
Ongoing
Country:
Germany
Principal investigator:
Gabriela Riemekasten
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Luebeck
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Brain changes in ME/CFS: Focus on the stress and immune system
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Inge Huitinga
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam), Netherlands Institute for Neuroscience (NIN), University of Amsterdam
Research period:
2023-01
to 2027-12
Research types:
Basic research
Research areas:
Nervous system dysfunction
Cell Morphology, Cell Deformability and Microclots in ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Annick Fehrer
Organisations:
Charité – University Medicine Berlin, Max Planck Institute for the Science of Light
Research period:
2024-01
to 2026-12
Research types:
Basic research
Research areas:
Hemic and lymphatic system dysfunction, Infections
Clinic and granulocytes
Project status:
Ongoing
Country:
Germany
Principal investigator:
Alexander Dejaco
Organisations:
University Clinic Regensburg
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Cardiovascular system dysfunction, General
Clinic, HDL proteome, and AI
Project status:
Ongoing
Country:
Germany
Principal investigator:
Elisabeth Schieffer
Organisations:
University Clinic Giessen and Marburg
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Clinical and immunological phenotyping and analysis of EBV autoantigens and autoantigens
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical and immunological phenotyping, analysis of autoantigens and T and B cell communication
Project status:
Ongoing
Country:
Germany
Principal investigator:
Birgit Sawitzki
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical characterisation for biomarker discovery
Project status:
Ongoing
Country:
Germany
Principal investigator:
Helena Radbruch
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Clinical characterisation, integrative morphological and functional studies of organ perfusion and biomarkers in patients with ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Wolfram Doehner
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Musculoskeletal system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Evidence and Effect of Serum Factors in Patients with ME/CFS after COVID-19 on Endothelial Cell Function In Vitro
Project status:
Ongoing
Country:
Germany
Principal investigator:
Kanchan Dulal
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Explaining skeletal muscle-related symptoms in patients with ME/CFS: from skeletal muscle to exercise immunology (MuscleME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Rob Wust
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam)
Research period:
2023-01
to 2027-11
Research types:
Basic research
Research areas:
Hemic and lymphatic system dysfunction, Musculoskeletal system dysfunction
Harmonised clinical phenotyping and biological signatures
Project status:
Ongoing
Country:
Germany
Principal investigator:
Martina Seifert
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction, General
Impact of the serum of Post-COVID-Syndrome patients without vs with ME/CFS on endothelial cell function
Project status:
Completed
Country:
Germany
Principal investigator:
Lavinia Flaskamp
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Importance of Raman spectroscopic signatures from blood cells in ME/CFS diagnostics
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anuradha Ramoji
Organisations:
Leibniz Institute of Photonic Technology
Research period:
Not available
Research types:
Basic research
Research areas:
General
Integrative transcriptome analyses of human and animal model samples for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Emanuel Wyler
Organisations:
Max Delbrück Center (MDC)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Investigation of PEM and ME/CFS-associated tryptophan metabotypes
Project status:
Ongoing
Country:
Germany
Principal investigator:
Konrad Aden
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Kiel, Kiel University (CAU)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Nutritional and metabolic system dysfunction
Muscle microclots and microvascular pathology in ME/CFS
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Rob Wust
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam)
Research period:
2024-07
to not available
Research types:
Basic research
Research areas:
Hemic and lymphatic system dysfunction, Musculoskeletal system dysfunction
The impact of mast cell activation on epithelial and endothelial barrier dysregulation in post-infectious ME/CFS (DegranulateME)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
FH Joanneum University of Applied Sciences, Medical University of Vienna
Research period:
2025-01
to 2025-12
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, Nutritional and metabolic system dysfunction, General
The molecular immune signature in ME/CFS as stratification tool for future personalized treatment (IMMUNESTRATIFY)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Willem A. Dik, Marjan Versnel
Organisations:
Erasmus Medical Center (Erasmus MC), Erasmus University Rotterdam
Research period:
2023-01
to 2027-12
Research types:
Basic research
Research areas:
Immune system dysfunction
Autoimmunity Risk Variants in the PTPN22 and CTLA4 Genes are Associated with Infectious Onset of ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Sophie Steiner
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction, Genetic risk factors, General
Genetic architecture of chronic fatigue syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Matthias Wielscher
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2025-12
Research types:
Basic research
Research areas:
Genetic risk factors, General
Development of Diagnostic Tests to Detect Autoantibodies in CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
Establishing Immunological Assays for the Diagnostics of ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Annick Fehrer
Organisations:
University Clinic Bonn, Charité – University Medicine Berlin, German Center for Neurodegenerative Diseases (DZNE)
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
Extracellular Vesicles from Plasma as Potential Biomarkers for an Improved Diagnosis of Endothelial Dysfunction in ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Diana Boristowski
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Functional autoantibodies against G-protein-coupled receptors in patients with ME/CFS (FAME)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Immune system dysfunction
Plasma Extracellular Vesicles as Potential Biomarkers for Endothelial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Martina Seifert
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction

Contact

ME/CFS Research Foundation

Ballindamm 27, 20095 Hamburg, Germany

researchregister@mecfs-research.org

Copyright © 2022 ME/CFS Research Foundation
Imprint - Data privacy statement