Research projects

Plasma Extracellular Vesicles as Potential Biomarkers for Endothelial Dysfunction in ME/CFS

About

Status:

Ongoing

Principal investigator:

Martina Seifert

Country:

Germany

Study start:

Not available

Completion (planned):

Not available

Last update:

2023-12-01

Research types:

Basic research

Research areas:

Cardiovascular system dysfunction

Interventions:

Not applicable

Priv. Sector Partner:

Not available

Sponsors:

German Association for ME/CFS

Links

Project website

Project description

The project aims to identify new biomarkers for ME/CFS from blood plasma. The researchers plan to isolate extracellular vesicles (EVs) from the plasma of ME/CFS patients as well as healthy subjects. These EVs will then be examined with regard to their characteristic spectrum of candidate molecules, such as microRNAs and proteins, as potential biomarkers for endothelial dysfunction. The discovery of such EV biomarkers could not only lead to an improved diagnosis, but also contribute to an expanded understanding of the underlying disorder of vascular function and the pathophysiology of ME/CFS.

(Description adapted from project website: see link above)

Patient cohort

Not available.

Patients enrolled: Not available

Age group: Not available

Research areas

2

Research types

1

Research networks

0

Working groups

1

People

1

Publications

0

Organisations

1

Research areas

Endothelial dysfunction

Endothelium is a layer of epithelium that lines the heart, blood vessels, lymph vessels, and the serous cavities of the body. The endothelium maintains an adequate homeostasis via its capacity to produce protective molecules. When this function is lost or damaged, endothelial dysfunction occurs, leading to a reduction in the capacity to maintain homeostasis and the development of pathologica...

Research projects:

Cardiovascular system dysfunction

The cardiovascular system includes the heart and the blood vessels by which blood is pumped and circulated throgh the body. Cardiovascular diseases describe pathological conditions involving the cardiovascular system, including the heart, blood vessels or the pericardium. Description adapted from: https://www.ncbi.nlm.nih.gov/mesh/68002319...

Research projects: