Research projects
This section of the ME/CFS Research Register (beta version) provides an overview of past and ongoing research projects on ME/CFS, starting from 2019. Projects include basic, clinical and epidemiological research. Click on a project to view its description and further details including research areas, types, and networks, as well as working groups, people, publications, and organisations connected with the research project.
A description of the register's current scope can be found on the starting page (Home).
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118 of 118 research projects
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A role of microbiome in the pathogenesis of ME/CFS: a population-based study
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Aleksandr Kurilshchikov
Organisations:
University of Groningen
Research period:
2023-01
to 2027-12
to 2027-12
Research types:
Epidemiological research
Research areas:
Digestive system dysfunction
ACT-CFS Pilot Study - Pilot Study to Evaluate an Innovative Activity Scale for Children and Adolescents with ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Adult patients with severe and very severe ME/CFS in Austria. A multi-perspective study.
Project status:
Ongoing
Country:
Austria
Principal investigator:
Kathryn Hoffmann
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
to 2026-03
Research types:
Epidemiological research
Research areas:
General
Altered Endothelial Dysfunction‐related miRs in Plasma from ME/CFS Patients
Project status:
Completed
Country:
Austria
Principal investigator:
Francisco Westermeier
Organisations:
FH Joanneum University of Applied Sciences, Warsaw University of Technology
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Analysing Antibody Responses against EBV-derived Antigens in ME/CFS
Project status:
Completed
Country:
Poland, UK, Germany
Principal investigator:
Carmen Scheibenbogen, Nuno Sepúlveda
Organisations:
Charité – University Medicine Berlin, Warsaw University of Technology
Research period:
2020-10
to not available
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Analysis of Blood Immune Cell Transcriptomes by Single-Cell RNA Sequencing (scRNA-seq)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anna Aschenbrenner
Organisations:
Charité – University Medicine Berlin, University Clinic Bonn, German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-10
to not available
to not available
Research types:
Clinical research
Research areas:
Hemic and lymphatic system dysfunction, General
Analysis of Differences in Plasma Proteins Using Mass Spectrometry
Project status:
Ongoing
Country:
Germany
Principal investigator:
Markus Ralser
Organisations:
Charité – University Medicine Berlin
Research period:
2022-10
to not available
to not available
Research types:
Clinical research
Research areas:
General
Analysis of Serum/Plasma Markers and Changes in Cellular Composition and Activation of Blood Cells
Project status:
Ongoing
Country:
Germany
Principal investigator:
Birgit Sawitzki
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
2022-10
to not available
to not available
Research types:
Clinical research
Research areas:
General
Antibody repertoires against microbiota as biomarkers for ME/CFS (CFSmicroAbs)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
A.P. (Alexandra) Zhernakova
Organisations:
University of Groningen
Research period:
2023-09
to 2027-09
to 2027-09
Research types:
Epidemiological research
Research areas:
Infections, Immune system dysfunction, Digestive system dysfunction, General
Application of Direct Current Transcranial Stimulation, Remotely Supervised in Chronic Fatigue (ACTIVATE)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Berthold Langguth
Organisations:
University of Regensburg
Research period:
2023-03
to 2025-01
to 2025-01
Research types:
Clinical research
Research areas:
Nervous system dysfunction
Assessing healthcare for patients with post-acute infection syndromes like ME/CFS (Care4PAIS&ME/CFS)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Golda Schlaff
Organisations:
Medical University of Vienna, University of Vienna
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Association Between EBV Reactivation and Development of Long-COVID Fatigue
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
Not available
Research types:
Basic research
Research areas:
Infections
Autoantibody-induced Transcriptome and Proteome as Biomarkers
Project status:
Ongoing
Country:
Germany
Principal investigator:
Gabriela Riemekasten
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Luebeck
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Autoimmunity Risk Variants in the PTPN22 and CTLA4 Genes are Associated with Infectious Onset of ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Sophie Steiner
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction, Genetic risk factors, General
Autoimmunity as a cause of ME/CFS symptoms (AutonoME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Jeroen den Dunnen
Organisations:
Amsterdam University Medical Center (Amsterdam UMC)
Research period:
2023-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Bavarian Network for Researching ME/CFS (BAYNET FOR ME/CFS)
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2022-10
to 2024-03
to 2024-03
Research types:
Epidemiological research
Research areas:
General
Biosamples, GPCR-Autoantibodies, Data Management and Bioinformatics
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Charité – University Medicine Berlin, University Clinic Schleswig-Holstein (UKSH) - Luebeck, Max Delbrück Center (MDC), Technical University of Munich (TUM)
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, General
Brain changes in ME/CFS: Focus on the stress and immune system
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Inge Huitinga
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam), Netherlands Institute for Neuroscience (NIN), University of Amsterdam
Research period:
2023-01
to 2027-12
to 2027-12
Research types:
Basic research
Research areas:
Nervous system dysfunction
COVID-19 Research Infrastructure Platform for Children and Adolescents (coverCHILD)
Project status:
Completed
Country:
Germany
Principal investigator:
Reinhard Berner, Ulrike Ravens-Sieberer
Organisations:
University Medical Center Hamburg-Eppendorf (UKE), University Clinic Dresden, University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2022-09
to 2023-12
to 2023-12
Research types:
Epidemiological research
Research areas:
General
COVIDOM: Longterm Morbidity of SARS-CoV-2 Infection and COVID-19 Disease - Consequences for Health Status and Quality of Life (NAPKON-POP)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Stefan Schreiber
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Kiel
Research period:
2020-11
to 2030-12
to 2030-12
Research types:
Epidemiological research
Research areas:
General
Care Model for Patients with ME/CFS (CFS_CARE)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin, Max Delbrück Center (MDC)
Research period:
2021-12
to 2024-12
to 2024-12
Research types:
Epidemiological research
Research areas:
General, Mental health
Care for ME/CFS
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Care situation and needs of young people with post-viral symptom complexes: Status quo analysis and development of a care concept (KidsCarePVS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2024-10
to 2027-09
to 2027-09
Research types:
Epidemiological research
Research areas:
General
Cell Morphology, Cell Deformability and Microclots in ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Annick Fehrer
Organisations:
Charité – University Medicine Berlin, Max Planck Institute for the Science of Light
Research period:
2024-01
to 2026-12
to 2026-12
Research types:
Basic research
Research areas:
Hemic and lymphatic system dysfunction, Infections
Characterisation of brain function and vascular pathology with a focus on autonomic dysfunctions during sleep
Project status:
Ongoing
Country:
Germany
Principal investigator:
Robert Goeder
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Kiel
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Chronic Fatigue Syndrome and Immunedeficiencies
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
2019-03
to not available
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinic and granulocytes
Project status:
Ongoing
Country:
Germany
Principal investigator:
Alexander Dejaco
Organisations:
University Clinic Regensburg
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Cardiovascular system dysfunction, General
Clinic, HDL proteome, and AI
Project status:
Ongoing
Country:
Germany
Principal investigator:
Elisabeth Schieffer
Organisations:
University Clinic Giessen and Marburg
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Clinical and immunological phenotyping and analysis of EBV autoantigens and autoantigens
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical and immunological phenotyping, analysis of autoantigens and T and B cell communication
Project status:
Ongoing
Country:
Germany
Principal investigator:
Birgit Sawitzki
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical characterisation for biomarker discovery
Project status:
Ongoing
Country:
Germany
Principal investigator:
Helena Radbruch
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Clinical characterisation, integrative morphological and functional studies of organ perfusion and biomarkers in patients with ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Wolfram Doehner
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Musculoskeletal system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Computer-based Clustering of Chronic Fatigue Syndrome Patients (CCCFS)
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna, University of Heidelberg
Research period:
2021-03
to 2022-03
to 2022-03
Research types:
Epidemiological research
Research areas:
General
Converging neurobiological and immune pathways in ME/CFS and post-infectious fatigue syndromes (PIFS)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Ruud Raijmakers
Organisations:
Radboud University Medical Centre (Radboud UMC)
Research period:
2023-01
to 2027-12
to 2027-12
Research types:
Epidemiological research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Endocrine system dysfunction, General
Deciphering systemic and mucosal antibody repertoires against the microbiota in ME/CFS and PCC (CFSabs)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Thomas Vogl
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
to 2026-03
Research types:
Basic research
Research areas:
Immune system dysfunction, Digestive system dysfunction
Decreased NO Production in Endothelial Cells Exposed to Plasma from ME/CFS Patients
Project status:
Completed
Country:
Austria
Principal investigator:
Jennifer Blauensteiner
Organisations:
FH Joanneum University of Applied Sciences
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Development and analysis of a SARS-CoV-2-induced golden hamster animal model for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Michael Muehlebach
Organisations:
Paul-Ehrlich-Institute (PEI)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Development and analysis of a SARS-CoV-2-induced mouse model for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Gregor Ebert
Organisations:
Helmholtz Munich
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Development and evaluation of interactive seminars for prospective doctors to destigmatise people with ME/CFS (SEE-ME)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christine Blome, Rachel Sommer
Organisations:
University Medical Center Hamburg-Eppendorf (UKE)
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Development of Diagnostic Tests to Detect Autoantibodies in CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
Diagnostic latency in ME/CFS and post-COVID: causes, consequences and potential for improvement – a mixed methods study (DiaMECO)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christine Blome
Organisations:
University Medical Center Hamburg-Eppendorf (UKE)
Research period:
2024-10
to 2027-09
to 2027-09
Research types:
Epidemiological research
Research areas:
General
EBV, SARS-CoV-2, HSV Mimicry Epitopes and Autoantibodies
Project status:
Ongoing
Country:
Germany
Principal investigator:
Franziska Sotzny
Organisations:
Charité – University Medicine Berlin, University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM), Helmholtz Munich
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, General
Effectiveness of Acceptance Commitment Therapy or Micro Breaks in Patients With CFS/ME
Project status:
Ongoing
Country:
Switzerland
Principal investigator:
Sarah Schiebler
Organisations:
University Hospital Zurich (USZ)
Research period:
2023-08
to 2026-07
to 2026-07
Research types:
Clinical research
Research areas:
General, Mental health
Endothelial Dysfunction and Altered Endothelial Biomarkers in Patients with Post-COVID-19 Syndrome and Chronic Fatigue Syndrome (ME/CFS)
Project status:
Completed
Country:
Germany
Principal investigator:
Milan Haffke
Organisations:
Charité – University Medicine Berlin, Max Delbrück Center (MDC), Berlin Institute of Health at Charité (BIH)
Research period:
Not available
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Endothelial Peripheral Arterial Tonometry (EndoPAT)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin, Berlin School of Mind and Brain
Research period:
2022-10
to not available
to not available
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Endothelial dysfunction in post-infection fatigue syndromes
Project status:
Ongoing
Country:
Austria, Germany
Principal investigator:
Francisco Westermeier
Organisations:
Charité – University Medicine Berlin, FH Joanneum University of Applied Sciences, Medical University of Vienna, Warsaw University of Technology
Research period:
2024-07
to 2027-06
to 2027-06
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Establishing Immunological Assays for the Diagnostics of ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Annick Fehrer
Organisations:
Charité – University Medicine Berlin, University Clinic Bonn, German Center for Neurodegenerative Diseases (DZNE)
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
Establishment of a Multicenter, Cross-Age Clinical ME/CFS Registry (MECFS-R) and Biobank (MECFS-Bio)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
Charité – University Medicine Berlin, University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2022-01
to 2024-12
to 2024-12
Research types:
Epidemiological research
Research areas:
General
Evaluation of retinal vascular analysis as a diagnostic marker in post-infectious ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christoph Schmaderer
Organisations:
University Hospital rechts der Isar (MRI TUM)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Evaluation of the link between auto-immunity and derangements in immune cell metabolism and function in ME/CFS (EnergiseME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Niels Eijkelkamp
Organisations:
University Medical Centre Utrecht (UMC Utrecht)
Research period:
2023-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Evidence and Effect of Serum Factors in Patients with ME/CFS after COVID-19 on Endothelial Cell Function In Vitro
Project status:
Ongoing
Country:
Germany
Principal investigator:
Kanchan Dulal
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Experiences of ME/CFS Patients in the German Healthcare System - A Qualitative Study on a Very Special Doctor-Patient Relationship
Project status:
Completed
Country:
Germany
Principal investigator:
Lotte Habermann-Horstmeier
Organisations:
Villingen Institute of Public Health (VIPH)
Research period:
2022-09
to not available
to not available
Research types:
Epidemiological research
Research areas:
General, Mental health
Explaining skeletal muscle-related symptoms in patients with ME/CFS: from skeletal muscle to exercise immunology (MuscleME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Rob Wust
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam)
Research period:
2023-01
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Hemic and lymphatic system dysfunction, Musculoskeletal system dysfunction
Exploring the Glycome: Identifying Glycosylation-Related Biomarkers for severity stratification in Chronic Fatigue Syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Davide Ret
Organisations:
Medical University of Vienna, Medical University of Graz, Technical University of Vienna
Research period:
2025-01
to 2025-12
to 2025-12
Research types:
Basic research
Research areas:
Immune system dysfunction
Extracellular Vesicles from Plasma as Potential Biomarkers for an Improved Diagnosis of Endothelial Dysfunction in ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Diana Boristowski
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Follow-Up of Respiratory Infections in Schleswig-Holstein (FRISH)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Folke Brinkmann
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Luebeck, Research Center Borstel, Leibniz Lung Center
Research period:
Not available
Research types:
Epidemiological research
Research areas:
Infections
Functional autoantibodies against G-protein-coupled receptors in patients with ME/CFS (FAME)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Immune system dysfunction
GaPaMUC-CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2020-09
to 2022-06
to 2022-06
Research types:
Epidemiological research
Research areas:
General
Genetic architecture of chronic fatigue syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Matthias Wielscher
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2025-12
to 2025-12
Research types:
Basic research
Research areas:
Genetic risk factors, General
HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS
Project status:
Completed
Country:
Latvia, Germany
Principal investigator:
Bhupesh K. Prusty
Organisations:
Charité – University Medicine Berlin, University Clinic Erlangen, University of Wuerzburg, University of California San Diego, Riga Stradins University
Research period:
Not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system dysfunction, General
Handgrip strength as a marker for muscular fatigue and fatigability in ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Bianka Jaekel
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
Not available
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction
Harmonisation and standardisation of the diagnosis of PEM in ME/CFS patients
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Clinical research
Research areas:
General
Harmonised clinical phenotyping and biological signatures
Project status:
Ongoing
Country:
Germany
Principal investigator:
Martina Seifert
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction, General
Health Care Workers Affected by Long COVID and Exhaustion/Fatigue (HALE Study)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Frauke Mattner
Organisations:
Clinics of the City of Cologne
Research period:
2022-07
to not available
to not available
Research types:
Epidemiological research
Research areas:
General
Hyperbaric High Pressure Oxygen Therapy (HBOT) in Post-COVID Syndrome and ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2023-07
to 2025-08
to 2025-08
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Identification of Characteristic Biological Factors of a Post-COVID-19 Syndrome (PRAM)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Evelyn Lamy
Organisations:
University of Augsburg
Research period:
2023-06
to 2024-12
to 2024-12
Research types:
Epidemiological research
Research areas:
Nutritional and metabolic system dysfunction, General
Identifying causal biological mechanisms in ME/CFS by a functional genetic approach
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
C. (Cindy) Boer
Organisations:
Erasmus Medical Center (Erasmus MC)
Research period:
2023-01
to 2027-12
to 2027-12
Research types:
Epidemiological research
Research areas:
Genetic risk factors
Immune Aberrations in Post-Infectious ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anna Aschenbrenner
Organisations:
Charité – University Medicine Berlin, University Clinic Bonn, German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Immune profiling and blood morphology analyses
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christian Puta
Organisations:
University Clinic Jena, Friedrich Schiller University Jena
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Clinical research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction, Nervous system dysfunction
Immunoadsorption in Patients With Chronic Fatigue Syndrome Including Patients With Post-COVID-19 CFS (IA-PACS-CFS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Harald Pruess
Organisations:
Charité – University Medicine Berlin, German Center for Neurodegenerative Diseases (DZNE)
Research period:
2023-10
to 2025-02
to 2025-02
Research types:
Clinical research
Research areas:
Immune system dysfunction
Immunoadsorption vs Sham Treatment in Post-COVID-19 Patients With Chronic Fatigue Syndrome (EXTINCT post COVID)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Vega Goedecke
Organisations:
Hannover Medical School (MHH)
Research period:
2023-07
to 2025-06
to 2025-06
Research types:
Clinical research
Research areas:
Immune system dysfunction
Impact of the serum of Post-COVID-Syndrome patients without vs with ME/CFS on endothelial cell function
Project status:
Completed
Country:
Germany
Principal investigator:
Lavinia Flaskamp
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Importance of Raman spectroscopic signatures from blood cells in ME/CFS diagnostics
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anuradha Ramoji
Organisations:
Leibniz Institute of Photonic Technology
Research period:
Not available
Research types:
Basic research
Research areas:
General
Improving the care situation for those affected by Long COVID (LCovB)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Johanna Schuster
Organisations:
Charité – University Medicine Berlin
Research period:
2024-03
to 2027-02
to 2027-02
Research types:
Epidemiological research
Research areas:
General
Infectious Triggers and Mitochondrial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2021-08
to not available
to not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system dysfunction
Instrument to support diagnosis, severity assessment, management and follow-up of post-viral syndromes in general practice (POSH)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Attila Altiner
Organisations:
University Clinic Heidelberg
Research period:
2024-07
to 2027-06
to 2027-06
Research types:
Epidemiological research
Research areas:
General
Integrated care of ME/CFS in children and adolescents using app-based telemonitoring
Project status:
Ongoing
Country:
Germany
Principal investigator:
Jeremy Schmidt, Zoe Oftring
Organisations:
University Clinic Giessen and Marburg, Clinic Bethel
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Integrative data analyses of human and animal model samples for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Volker Bruns
Organisations:
Fraunhofer Institute for Integrated Circuits (IIS)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Integrative transcriptome analyses of human and animal model samples for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Emanuel Wyler
Organisations:
Max Delbrück Center (MDC)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Investigating Cerebral Oxygen Metabolism Dysfunction as a pathomechanism of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Lucas Haider
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-02
to 2026-02
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Investigation of PEM and ME/CFS-associated changes in tryptophan metabolism at the host and microbiome level
Project status:
Ongoing
Country:
Germany
Principal investigator:
Silvio Waschina
Organisations:
Kiel University (CAU)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Nutritional and metabolic system dysfunction, Digestive system dysfunction
Investigation of PEM and ME/CFS-associated tryptophan metabotypes
Project status:
Ongoing
Country:
Germany
Principal investigator:
Konrad Aden
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Kiel, Kiel University (CAU)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Nutritional and metabolic system dysfunction
ME/CFS Biobank Austria
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
2023-09
to not available
to not available
Research types:
Basic research
Research areas:
General
ME/CFS Kids Bavaria
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2021-12
to 2023-12
to 2023-12
Research types:
Epidemiological research
Research areas:
General
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) (PoCoVIT)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christiana Franke
Organisations:
Charité – University Medicine Berlin
Research period:
2023-10
to 2025-03
to 2025-03
Research types:
Clinical research
Research areas:
Immune system dysfunction, Nervous system dysfunction
Mitochondrial Dysfunction and Metabolic Changes
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Mobile sleep studies in adolescents
Project status:
Ongoing
Country:
Germany
Principal investigator:
Insa Wolf
Organisations:
Fraunhofer Institute for Digital Media Technology (IDMT)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Molecular immunological characterisation & multimodal-multicenter intersectoral care for Long COVID in children and adolescents in Baden-Wuerttemberg (MOVE-COVID-BW)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Roland Elling
Organisations:
University Clinic Freiburg
Research period:
2023-10
to 2024-12
to 2024-12
Research types:
Epidemiological research
Research areas:
General
Multimodal characterisation of brain function and blood flow, neuronal metabolism and genetic risk structure
Project status:
Ongoing
Country:
Germany
Principal investigator:
Claudia Schilling
Organisations:
Central Institute of Mental Health (CIMH)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Munich Cohort Study With Biobank for Children, Adolescents, and Young Adults With Post-infection ME/CFS (MUC-CFS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2019-01
to 2029-01
to 2029-01
Research types:
Epidemiological research
Research areas:
General
Muscle microclots and microvascular pathology in ME/CFS
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Rob Wust
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam)
Research period:
2024-07
to not available
to not available
Research types:
Basic research
Research areas:
Hemic and lymphatic system dysfunction, Musculoskeletal system dysfunction
Observational Study of the Effect of Immunoadsorption (IA) in Patients < 18 Years of Age with ME/CFS with Evidence of Autoantibodies (BIAKI)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Wolfgang Ries
Organisations:
DIAKO Hospital
Research period:
2023-11
to 2025-11
to 2025-11
Research types:
Clinical research
Research areas:
Immune system dysfunction
Occurence and Characterization of the Chronic Fatigue Syndrome in the Berlin Subcohort of the Population-Based NAPKON-POP (COVIDOM) Study
Project status:
Ongoing
Country:
Germany
Principal investigator:
Lilian Krist
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Optical Coherence Tomography Angiography (OCT-A) and Non-invasive Dynamic Vessel Analysis (DVA)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin, Berlin School of Mind and Brain, Max Delbrück Center (MDC)
Research period:
2022-10
to not available
to not available
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/CFS (POTS-CFS)
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), University Clinic Aachen, Technical University of Munich (TUM)
Research period:
2021-12
to 2022-11
to 2022-11
Research types:
Epidemiological research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Plasma Extracellular Vesicles as Potential Biomarkers for Endothelial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Martina Seifert
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Post Acute Infection Syndromes Interdisciplinary Care Berlin (PAIS Care Berlin)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin, Max Delbrück Center (MDC)
Research period:
2024-11
to 2028-12
to 2028-12
Research types:
Epidemiological research
Research areas:
General
Post-COVID-Kids Bavaria 1.0
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends, Michael Kabesch
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM), Barmherzige Brüder Clinic St. Hedwig Regensburg
Research period:
2021-09
to 2023-06
to 2023-06
Research types:
Epidemiological research
Research areas:
General
Post-COVID-Kids Bavaria 2.0
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2023-09
to 2024-12
to 2024-12
Research types:
Epidemiological research
Research areas:
General
Post-exertional malaise: a starting point to study and understand ME/CFS
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
C.A.T. (Inge) Zijdewind
Organisations:
University of Groningen
Research period:
2023-01
to 2027-12
to 2027-12
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Raman spectroscopic signatures of blood cells
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anuradha Ramoji
Organisations:
Leibniz Institute of Photonic Technology
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction
Repeat Immunoadsorption Post Covid ME/CFS (RIA)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2022-08
to 2025-01
to 2025-01
Research types:
Clinical research
Research areas:
Immune system dysfunction
Skeletal Muscle Structure and Function in Relation to Post-exertional Malaise in Patients With PASC and ME/CFS
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Michele van Vugt
Organisations:
Amsterdam University Medical Center (Amsterdam UMC)
Research period:
2022-01
to 2025-12
to 2025-12
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction
Sodium Content in Lower Leg Muscle in Patients with ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Elisabeth Petter
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction, Nutritional and metabolic system dysfunction
Structural and Functional MRI Studies and Accompanying Arterial Spin Labeling (ASL)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin, Berlin School of Mind and Brain, Max Delbrück Center (MDC)
Research period:
2022-10
to not available
to not available
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Study on Infectious Mononucleosis in Munich (IMMUC)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2017-03
to 2025-12
to 2025-12
Research types:
Epidemiological research
Research areas:
Infections
Study on Long COVID and ME/CFS Symptoms in Patients with Mental Disabilities and the Experiences of Patients, Relatives and Carers in the German Healthcare System
Project status:
Ongoing
Country:
Germany
Principal investigator:
Lotte Habermann-Horstmeier
Organisations:
Villingen Institute of Public Health (VIPH)
Research period:
2022-09
to not available
to not available
Research types:
Epidemiological research
Research areas:
General, Mental health
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome (VERI-LONG)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Judith Bellmann-Strobl
Organisations:
Charité – University Medicine Berlin, Max Delbrück Center (MDC)
Research period:
2023-06
to 2025-04
to 2025-04
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Swiss ME/CFS Study
Project status:
Completed
Country:
Switzerland
Principal investigator:
Rea Tschopp
Organisations:
Swiss Tropical And Public Health Institute, University of Basel
Research period:
2021-06
to not available
to not available
Research types:
Epidemiological research
Research areas:
General, Mental health
TeleNeurological outpatient care in Brandenburg and Mecklenburg-Western Pomerania (TENEAM)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christiana Franke
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
The Role of Hidden Viral Infections in Peripheral Blood and Gut-Specific Lymphatic Tissue in the Pathogenesis of ME/CFS (UNRAVELING ME/CFS)
Project status:
Ongoing
Country:
USA, Austria
Principal investigator:
Alexander Zoufaly
Organisations:
Clinic Favoriten Vienna, Cornell University
Research period:
Not available
Research types:
Epidemiological research
Research areas:
Hemic and lymphatic system dysfunction, Infections, General
The impact of mast cell activation on epithelial and endothelial barrier dysregulation in post-infectious ME/CFS (DegranulateME)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
FH Joanneum University of Applied Sciences, Medical University of Vienna
Research period:
2025-01
to 2025-12
to 2025-12
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, Nutritional and metabolic system dysfunction, General
The molecular immune signature in ME/CFS as stratification tool for future personalized treatment (IMMUNESTRATIFY)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Willem A. Dik, Marjan Versnel
Organisations:
Erasmus Medical Center (Erasmus MC), Erasmus University Rotterdam
Research period:
2023-01
to 2027-12
to 2027-12
Research types:
Basic research
Research areas:
Immune system dysfunction
The role of the skeletal muscle and myocardial metabolism in ME/CFS: in vivo MRS study.
Project status:
Ongoing
Country:
Austria
Principal investigator:
Martin Krssak
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
to 2026-03
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Treatment courses and determinants in Long COVID and other post-viral symptom complexes (BD-LC-PS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Thomas Grobe
Organisations:
aQua Institute
Research period:
2025-04
to 2028-03
to 2028-03
Research types:
Epidemiological research
Research areas:
General
Understanding Potential Infectious Triggers and Mitochondrial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2025-01
to not available
to not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system dysfunction
Unraveling Endothelial Function in ME/CFS
Project status:
Ongoing
Country:
Austria
Principal investigator:
Francisco Westermeier
Organisations:
FH Joanneum University of Applied Sciences, Warsaw University of Technology, Medical University of Graz
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
unCOVer Erlangen - ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
Not available
Research types:
Clinical research
Research areas:
Immune system dysfunction
Contact
ME/CFS Research Foundation
Ballindamm 27, 20095 Hamburg, Germany
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