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Research projects

This section of the ME/CFS Research Register (beta version) provides an overview of past and ongoing research projects on ME/CFS, starting from 2019. Projects include basic, clinical and epidemiological research. Click on a project to see its description and further details including research areas, types, and networks, as well as working groups, selected people, publications, and organisations (hosting involved working groups) connected with the project. Use the search function to look for specific topics, areas or types of research, for example. A description of the register's current scope can be found on the starting page (Home).
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117 of 117 research projects

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A role of microbiome in the pathogenesis of ME/CFS: a population-based study
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Aleksandr Kurilshchikov
Organisations:
University of Groningen
Research period:
2023-01
to 2027-12
Research types:
Epidemiological research
Research areas:
Digestive system dysfunction
ACT-CFS Pilot Study - Pilot Study to Evaluate an Innovative Activity Scale for Children and Adolescents with ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Adult patients with severe and very severe ME/CFS in Austria. A multi-perspective study.
Project status:
Ongoing
Country:
Austria
Principal investigator:
Kathryn Hoffmann
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
Research types:
Epidemiological research
Research areas:
General
Altered Endothelial Dysfunction‐related miRs in Plasma from ME/CFS Patients
Project status:
Completed
Country:
Austria
Principal investigator:
Francisco Westermeier
Organisations:
FH Joanneum University of Applied Sciences,Warsaw University of Technology
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Analysing Antibody Responses against EBV-derived Antigens in ME/CFS
Project status:
Completed
Country:
Poland, UK, Germany
Principal investigator:
Carmen Scheibenbogen, Nuno Sepúlveda
Organisations:
Charité – University Medicine Berlin,Warsaw University of Technology
Research period:
2020-10
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Analysis of Blood Immune Cell Transcriptomes by Single-Cell RNA Sequencing (scRNA-seq)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anna Aschenbrenner
Organisations:
Charité – University Medicine Berlin,University Clinic Bonn,German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
Hemic and lymphatic system dysfunction, General
Analysis of Differences in Plasma Proteins Using Mass Spectrometry
Project status:
Ongoing
Country:
Germany
Principal investigator:
Markus Ralser
Organisations:
Charité – University Medicine Berlin
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
General
Analysis of Serum/Plasma Markers and Changes in Cellular Composition and Activation of Blood Cells
Project status:
Ongoing
Country:
Germany
Principal investigator:
Birgit Sawitzki
Organisations:
Charité – University Medicine Berlin,Berlin Institute of Health at Charité (BIH)
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
General
Antibody repertoires against microbiota as biomarkers for ME/CFS (CFSmicroAbs)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
A.P. (Alexandra) Zhernakova
Organisations:
University of Groningen
Research period:
2023-09
to 2027-09
Research types:
Epidemiological research
Research areas:
Infections, Immune system dysfunction, Digestive system dysfunction, General
Application of Direct Current Transcranial Stimulation, Remotely Supervised in Chronic Fatigue (ACTIVATE)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Berthold Langguth
Organisations:
University of Regensburg
Research period:
2023-03
to 2025-01
Research types:
Clinical research
Research areas:
Nervous system dysfunction
Assessing healthcare for patients with post-acute infection syndromes like ME/CFS (Care4PAIS&ME/CFS)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Golda Schlaff
Organisations:
Medical University of Vienna,University of Vienna
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Association Between EBV Reactivation and Development of Long-COVID Fatigue
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
Not available
Research types:
Basic research
Research areas:
Infections
Autoantibody-induced Transcriptome and Proteome as Biomarkers
Project status:
Ongoing
Country:
Germany
Principal investigator:
Gabriela Riemekasten
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Luebeck
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Autoimmunity Risk Variants in the PTPN22 and CTLA4 Genes are Associated with Infectious Onset of ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Sophie Steiner
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction, Genetic risk factors, General
Autoimmunity as a cause of ME/CFS symptoms (AutonoME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Jeroen den Dunnen
Organisations:
Amsterdam University Medical Center (Amsterdam UMC)
Research period:
2023-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Bavarian Network for Researching ME/CFS (BAYNET FOR ME/CFS)
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2022-10
to 2024-03
Research types:
Epidemiological research
Research areas:
General
Biosamples, GPCR-Autoantibodies, Data Management and Bioinformatics
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Charité – University Medicine Berlin,University Clinic Schleswig-Holstein (UKSH) - Luebeck,Max Delbrück Center (MDC),Technical University of Munich (TUM)
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, General
Brain changes in ME/CFS: Focus on the stress and immune system
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Inge Huitinga
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam),Netherlands Institute for Neuroscience (NIN),University of Amsterdam
Research period:
2023-01
to 2027-12
Research types:
Basic research
Research areas:
Nervous system dysfunction
COVID-19 Research Infrastructure Platform for Children and Adolescents (coverCHILD)
Project status:
Completed
Country:
Germany
Principal investigator:
Reinhard Berner, Ulrike Ravens-Sieberer
Organisations:
University Clinic Dresden,University Hospital rechts der Isar (MRI TUM),University Medical Center Hamburg-Eppendorf (UKE),Technical University of Munich (TUM)
Research period:
2022-09
to 2023-12
Research types:
Epidemiological research
Research areas:
General
COVIDOM: Longterm Morbidity of SARS-CoV-2 Infection and COVID-19 Disease - Consequences for Health Status and Quality of Life (NAPKON-POP)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Stefan Schreiber
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Kiel
Research period:
2020-11
to 2030-12
Research types:
Epidemiological research
Research areas:
General
Care Model for Patients with ME/CFS (CFS_CARE)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2021-12
to 2024-12
Research types:
Epidemiological research
Research areas:
General, Mental health
Care for ME/CFS
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Care situation and needs of young people with post-viral symptom complexes: Status quo analysis and development of a care concept (KidsCarePVS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2024-10
to 2027-09
Research types:
Epidemiological research
Research areas:
General
Cell Morphology, Cell Deformability and Microclots in ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Annick Fehrer
Organisations:
Charité – University Medicine Berlin,Max Planck Institute for the Science of Light
Research period:
2024-01
to 2026-12
Research types:
Basic research
Research areas:
Hemic and lymphatic system dysfunction, Infections
Characterisation of brain function and vascular pathology with a focus on autonomic dysfunctions during sleep
Project status:
Ongoing
Country:
Germany
Principal investigator:
Robert Goeder
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Kiel
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Chronic Fatigue Syndrome and Immunedeficiencies
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
2019-03
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinic and granulocytes
Project status:
Ongoing
Country:
Germany
Principal investigator:
Alexander Dejaco
Organisations:
University Clinic Regensburg
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Cardiovascular system dysfunction, General
Clinic, HDL proteome, and AI
Project status:
Ongoing
Country:
Germany
Principal investigator:
Elisabeth Schieffer
Organisations:
University Clinic Giessen and Marburg
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Clinical and immunological phenotyping and analysis of EBV autoantigens and autoantigens
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical and immunological phenotyping, analysis of autoantigens and T and B cell communication
Project status:
Ongoing
Country:
Germany
Principal investigator:
Birgit Sawitzki
Organisations:
Charité – University Medicine Berlin,Berlin Institute of Health at Charité (BIH)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical characterisation for biomarker discovery
Project status:
Ongoing
Country:
Germany
Principal investigator:
Helena Radbruch
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Clinical characterisation, integrative morphological and functional studies of organ perfusion and biomarkers in patients with ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Wolfram Doehner
Organisations:
Charité – University Medicine Berlin,Berlin Institute of Health at Charité (BIH)
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Musculoskeletal system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Computer-based Clustering of Chronic Fatigue Syndrome Patients (CCCFS)
Project status:
Completed
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna,University of Heidelberg
Research period:
2021-03
to 2022-03
Research types:
Epidemiological research
Research areas:
General
Converging neurobiological and immune pathways in ME/CFS and post-infectious fatigue syndromes (PIFS)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Ruud Raijmakers
Organisations:
Radboud University Medical Centre (Radboud UMC)
Research period:
2023-01
to 2027-12
Research types:
Epidemiological research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Endocrine system dysfunction, General
Deciphering systemic and mucosal antibody repertoires against the microbiota in ME/CFS and PCC (CFSabs)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Thomas Vogl
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
Research types:
Basic research
Research areas:
Immune system dysfunction, Digestive system dysfunction
Decreased NO Production in Endothelial Cells Exposed to Plasma from ME/CFS Patients
Project status:
Completed
Country:
Austria
Principal investigator:
Jennifer Blauensteiner
Organisations:
FH Joanneum University of Applied Sciences
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Development and analysis of a SARS-CoV-2-induced golden hamster animal model for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Michael Muehlebach
Organisations:
Paul-Ehrlich-Institute (PEI)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Development and analysis of a SARS-CoV-2-induced mouse model for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Gregor Ebert
Organisations:
Helmholtz Munich
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Development and evaluation of interactive seminars for prospective doctors to destigmatise people with ME/CFS (SEE-ME)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christine Blome, Rachel Sommer
Organisations:
University Medical Center Hamburg-Eppendorf (UKE)
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Development of Diagnostic Tests to Detect Autoantibodies in CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
Diagnostic latency in ME/CFS and post-COVID: causes, consequences and potential for improvement – ​​a mixed methods study (DiaMECO)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christine Blome
Organisations:
University Medical Center Hamburg-Eppendorf (UKE)
Research period:
2024-10
to 2027-09
Research types:
Epidemiological research
Research areas:
General
EBV, SARS-CoV-2, HSV Mimicry Epitopes and Autoantibodies
Project status:
Ongoing
Country:
Germany
Principal investigator:
Franziska Sotzny
Organisations:
University Hospital rechts der Isar (MRI TUM),Charité – University Medicine Berlin,Technical University of Munich (TUM),Helmholtz Munich
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, General
Effectiveness of Acceptance Commitment Therapy or Micro Breaks in Patients With CFS/ME
Project status:
Ongoing
Country:
Switzerland
Principal investigator:
Sarah Schiebler
Organisations:
University Hospital Zurich (USZ)
Research period:
2023-08
to 2026-07
Research types:
Clinical research
Research areas:
General, Mental health
Endothelial Dysfunction and Altered Endothelial Biomarkers in Patients with Post-COVID-19 Syndrome and Chronic Fatigue Syndrome (ME/CFS)
Project status:
Completed
Country:
Germany
Principal investigator:
Milan Haffke
Organisations:
Charité – University Medicine Berlin,Max Delbrück Center (MDC),Berlin Institute of Health at Charité (BIH)
Research period:
Not available
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Endothelial Peripheral Arterial Tonometry (EndoPAT)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin,Berlin School of Mind and Brain
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Endothelial dysfunction in post-infection fatigue syndromes
Project status:
Ongoing
Country:
Austria, Germany
Principal investigator:
Francisco Westermeier
Organisations:
Charité – University Medicine Berlin,FH Joanneum University of Applied Sciences,Medical University of Vienna,Warsaw University of Technology
Research period:
2024-07
to 2027-06
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Establishing Immunological Assays for the Diagnostics of ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Annick Fehrer
Organisations:
Charité – University Medicine Berlin,University Clinic Bonn,German Center for Neurodegenerative Diseases (DZNE)
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
Evaluation of retinal vascular analysis as a diagnostic marker in post-infectious ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christoph Schmaderer
Organisations:
University Hospital rechts der Isar (MRI TUM)
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Evaluation of the link between auto-immunity and derangements in immune cell metabolism and function in ME/CFS (EnergiseME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Niels Eijkelkamp
Organisations:
University Medical Centre Utrecht (UMC Utrecht)
Research period:
2023-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Evidence and Effect of Serum Factors in Patients with ME/CFS after COVID-19 on Endothelial Cell Function In Vitro
Project status:
Ongoing
Country:
Germany
Principal investigator:
Kanchan Dulal
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Experiences of ME/CFS Patients in the German Healthcare System - A Qualitative Study on a Very Special Doctor-Patient Relationship
Project status:
Completed
Country:
Germany
Principal investigator:
Lotte Habermann-Horstmeier
Organisations:
Villingen Institute of Public Health (VIPH)
Research period:
2022-09
to not available
Research types:
Epidemiological research
Research areas:
General, Mental health
Explaining skeletal muscle-related symptoms in patients with ME/CFS: from skeletal muscle to exercise immunology (MuscleME)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Rob Wust
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam)
Research period:
2023-01
to 2027-11
Research types:
Basic research
Research areas:
Hemic and lymphatic system dysfunction, Musculoskeletal system dysfunction
Exploring the Glycome: Identifying Glycosylation-Related Biomarkers for severity stratification in Chronic Fatigue Syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Davide Ret
Organisations:
Medical University of Vienna,Medical University of Graz,Technical University of Vienna
Research period:
2025-01
to 2025-12
Research types:
Basic research
Research areas:
Immune system dysfunction
Extracellular Vesicles from Plasma as Potential Biomarkers for an Improved Diagnosis of Endothelial Dysfunction in ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Diana Boristowski
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Follow-Up of Respiratory Infections in Schleswig-Holstein (FRISH)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Folke Brinkmann
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Luebeck,Research Center Borstel, Leibniz Lung Center
Research period:
Not available
Research types:
Epidemiological research
Research areas:
Infections
Functional autoantibodies against G-protein-coupled receptors in patients with ME/CFS (FAME)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Immune system dysfunction
GaPaMUC-CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2020-09
to 2022-06
Research types:
Epidemiological research
Research areas:
General
Genetic architecture of chronic fatigue syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Matthias Wielscher
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2025-12
Research types:
Basic research
Research areas:
Genetic risk factors, General
HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS
Project status:
Completed
Country:
Latvia, Germany
Principal investigator:
Bhupesh K. Prusty
Organisations:
Charité – University Medicine Berlin,University Clinic Erlangen,University of Wuerzburg,University of California San Diego,Riga Stradins University
Research period:
Not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system dysfunction, General
Handgrip strength as a marker for muscular fatigue and fatigability in ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Bianka Jaekel
Organisations:
Charité – University Medicine Berlin,Berlin Institute of Health at Charité (BIH)
Research period:
Not available
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction
Harmonisation and standardisation of the diagnosis of PEM in ME/CFS patients
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
General
Harmonised clinical phenotyping and biological signatures
Project status:
Ongoing
Country:
Germany
Principal investigator:
Martina Seifert
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction, General
Health Care Workers Affected by Long COVID and Exhaustion/Fatigue (HALE Study)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Frauke Mattner
Organisations:
Clinics of the City of Cologne
Research period:
2022-07
to not available
Research types:
Epidemiological research
Research areas:
General
Hyperbaric High Pressure Oxygen Therapy (HBOT) in Post-COVID Syndrome and ME/​CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2023-07
to 2025-08
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Identification of Characteristic Biological Factors of a Post-COVID-19 Syndrome (PRAM)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Evelyn Lamy
Organisations:
University of Augsburg
Research period:
2023-06
to 2024-12
Research types:
Epidemiological research
Research areas:
Nutritional and metabolic system dysfunction, General
Identifying causal biological mechanisms in ME/CFS by a functional genetic approach
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
C. (Cindy) Boer
Organisations:
Erasmus Medical Center (Erasmus MC)
Research period:
2023-01
to 2027-12
Research types:
Epidemiological research
Research areas:
Genetic risk factors
Immune Aberrations in Post-Infectious ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anna Aschenbrenner
Organisations:
Charité – University Medicine Berlin,University Clinic Bonn,German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Immune profiling and blood morphology analyses
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christian Puta
Organisations:
University Clinic Jena,Friedrich Schiller University Jena
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction, Nervous system dysfunction
Immunoadsorption in Patients With Chronic Fatigue Syndrome Including Patients With Post-COVID-19 CFS (IA-PACS-CFS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Harald Pruess
Organisations:
Charité – University Medicine Berlin,German Center for Neurodegenerative Diseases (DZNE)
Research period:
2023-10
to 2025-02
Research types:
Clinical research
Research areas:
Immune system dysfunction
Immunoadsorption vs Sham Treatment in Post-COVID-19 Patients With Chronic Fatigue Syndrome (EXTINCT post COVID)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Vega Goedecke
Organisations:
Hannover Medical School (MHH)
Research period:
2023-07
to 2025-06
Research types:
Clinical research
Research areas:
Immune system dysfunction
Impact of the serum of Post-COVID-Syndrome patients without vs with ME/CFS on endothelial cell function
Project status:
Completed
Country:
Germany
Principal investigator:
Lavinia Flaskamp
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Importance of Raman spectroscopic signatures from blood cells in ME/CFS diagnostics
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anuradha Ramoji
Organisations:
Leibniz Institute of Photonic Technology
Research period:
Not available
Research types:
Basic research
Research areas:
General
Improving the care situation for those affected by Long COVID (LCovB)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Johanna Schuster
Organisations:
Charité – University Medicine Berlin
Research period:
2024-03
to 2027-02
Research types:
Epidemiological research
Research areas:
General
Infectious Triggers and Mitochondrial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2021-08
to not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system dysfunction
Instrument to support diagnosis, severity assessment, management and follow-up of post-viral syndromes in general practice (POSH)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Attila Altiner
Organisations:
University Clinic Heidelberg
Research period:
2024-07
to 2027-06
Research types:
Epidemiological research
Research areas:
General
Integrated care of ME/CFS in children and adolescents using app-based telemonitoring
Project status:
Ongoing
Country:
Germany
Principal investigator:
Jeremy Schmidt, Zoe Oftring
Organisations:
University Clinic Giessen and Marburg,Clinic Bethel
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Integrative data analyses of human and animal model samples for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Volker Bruns
Organisations:
Fraunhofer Institute for Integrated Circuits (IIS)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Integrative transcriptome analyses of human and animal model samples for ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Emanuel Wyler
Organisations:
Max Delbrück Center (MDC)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Investigating Cerebral Oxygen Metabolism Dysfunction as a pathomechanism of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Lucas Haider
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-02
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Investigation of PEM and ME/CFS-associated changes in tryptophan metabolism at the host and microbiome level
Project status:
Ongoing
Country:
Germany
Principal investigator:
Silvio Waschina
Organisations:
Kiel University (CAU)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Nutritional and metabolic system dysfunction, Digestive system dysfunction
Investigation of PEM and ME/CFS-associated tryptophan metabotypes
Project status:
Ongoing
Country:
Germany
Principal investigator:
Konrad Aden
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Kiel,Kiel University (CAU)
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Nutritional and metabolic system dysfunction
ME/CFS Biobank Austria
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
2023-09
to not available
Research types:
Basic research
Research areas:
General
ME/CFS Kids Bavaria
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2021-12
to 2023-12
Research types:
Epidemiological research
Research areas:
General
ME/CFS Registry and Biobank (MECFS-R & MECFS-Bio)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Charité – University Medicine Berlin,Technical University of Munich (TUM)
Research period:
2022-01
to 2024-12
Research types:
Epidemiological research
Research areas:
General
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) (PoCoVIT)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christiana Franke
Organisations:
Charité – University Medicine Berlin
Research period:
2023-10
to 2025-03
Research types:
Clinical research
Research areas:
Immune system dysfunction, Nervous system dysfunction
Mitochondrial Dysfunction and Metabolic Changes
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2022-08
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Mobile sleep studies in adolescents
Project status:
Ongoing
Country:
Germany
Principal investigator:
Insa Wolf
Organisations:
Fraunhofer Institute for Digital Media Technology (IDMT)
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Molecular immunological characterisation & multimodal-multicenter intersectoral care for Long COVID in children and adolescents in Baden-Wuerttemberg (MOVE-COVID-BW)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Roland Elling
Organisations:
University Clinic Freiburg
Research period:
2023-10
to 2024-12
Research types:
Epidemiological research
Research areas:
General
Multimodal characterisation of brain function and blood flow, neuronal metabolism and genetic risk structure
Project status:
Ongoing
Country:
Germany
Principal investigator:
Claudia Schilling
Organisations:
Central Institute of Mental Health (CIMH)
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Munich Cohort Study With Biobank for Children, Adolescents, and Young Adults With Post-infection ME/CFS (MUC-CFS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2019-01
to 2029-01
Research types:
Epidemiological research
Research areas:
General
Muscle microclots and microvascular pathology in ME/CFS
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Rob Wust
Organisations:
Vrije Universiteit Amsterdam (VU Amsterdam)
Research period:
2024-07
to not available
Research types:
Basic research
Research areas:
Hemic and lymphatic system dysfunction, Musculoskeletal system dysfunction
Observational Study of the Effect of Immunoadsorption (IA) in Patients < 18 Years of Age with ME/CFS with Evidence of Autoantibodies (BIAKI)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Wolfgang Ries
Organisations:
DIAKO Hospital
Research period:
2023-11
to 2025-11
Research types:
Clinical research
Research areas:
Immune system dysfunction
Occurence and Characterization of the Chronic Fatigue Syndrome in the Berlin Subcohort of the Population-Based NAPKON-POP (COVIDOM) Study
Project status:
Ongoing
Country:
Germany
Principal investigator:
Lilian Krist
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Epidemiological research
Research areas:
General
Optical Coherence Tomography Angiography (OCT-A) and Non-invasive Dynamic Vessel Analysis (DVA)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin,Berlin School of Mind and Brain,Max Delbrück Center (MDC)
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/​CFS (POTS-CFS)
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),University Clinic Aachen,Technical University of Munich (TUM)
Research period:
2021-12
to 2022-11
Research types:
Epidemiological research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Plasma Extracellular Vesicles as Potential Biomarkers for Endothelial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Martina Seifert
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
Post Acute Infection Syndromes Interdisciplinary Care Berlin (PAIS Care Berlin)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2028-12
Research types:
Epidemiological research
Research areas:
General
Post-COVID-Kids Bavaria 1.0
Project status:
Completed
Country:
Germany
Principal investigator:
Uta Behrends, Michael Kabesch
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM),Barmherzige Brüder Clinic St. Hedwig Regensburg
Research period:
2021-09
to 2023-06
Research types:
Epidemiological research
Research areas:
General
Post-COVID-Kids Bavaria 2.0
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2023-09
to 2024-12
Research types:
Epidemiological research
Research areas:
General
Post-exertional malaise: a starting point to study and understand ME/CFS
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
C.A.T. (Inge) Zijdewind
Organisations:
University of Groningen
Research period:
2023-01
to 2027-12
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Raman spectroscopic signatures of blood cells
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anuradha Ramoji
Organisations:
Leibniz Institute of Photonic Technology
Research period:
2024-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction
Repeat Immunoadsorption Post Covid ME/​CFS (RIA)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2022-08
to 2025-01
Research types:
Clinical research
Research areas:
Immune system dysfunction
Skeletal Muscle Structure and Function in Relation to Post-exertional Malaise in Patients With PASC and ME/CFS
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Michele van Vugt
Organisations:
Amsterdam University Medical Center (Amsterdam UMC)
Research period:
2022-01
to 2025-12
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction
Sodium Content in Lower Leg Muscle in Patients with ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Elisabeth Petter
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction, Nutritional and metabolic system dysfunction
Structural and Functional MRI Studies and Accompanying Arterial Spin Labeling (ASL)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin,Berlin School of Mind and Brain,Max Delbrück Center (MDC)
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Study on Infectious Mononucleosis in Munich (IMMUC)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2017-03
to 2025-12
Research types:
Epidemiological research
Research areas:
Infections
Study on Long COVID and ME/CFS Symptoms in Patients with Mental Disabilities and the Experiences of Patients, Relatives and Carers in the German Healthcare System
Project status:
Ongoing
Country:
Germany
Principal investigator:
Lotte Habermann-Horstmeier
Organisations:
Villingen Institute of Public Health (VIPH)
Research period:
2022-09
to not available
Research types:
Epidemiological research
Research areas:
General, Mental health
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome (VERI-LONG)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Judith Bellmann-Strobl
Organisations:
Charité – University Medicine Berlin,Max Delbrück Center (MDC)
Research period:
2023-06
to 2025-04
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Swiss ME/CFS Study
Project status:
Completed
Country:
Switzerland
Principal investigator:
Rea Tschopp
Organisations:
Swiss Tropical And Public Health Institute,University of Basel
Research period:
2021-06
to 2021-09
Research types:
Epidemiological research
Research areas:
General, Mental health
The Role of Hidden Viral Infections in Peripheral Blood and Gut-Specific Lymphatic Tissue in the Pathogenesis of ME/CFS (UNRAVELING ME/CFS)
Project status:
Ongoing
Country:
USA, Austria
Principal investigator:
Alexander Zoufaly
Organisations:
Clinic Favoriten Vienna,Cornell University
Research period:
Not available
Research types:
Epidemiological research
Research areas:
Hemic and lymphatic system dysfunction, Infections, General
The impact of mast cell activation on epithelial and endothelial barrier dysregulation in post-infectious ME/CFS (DegranulateME)
Project status:
Ongoing
Country:
Austria
Principal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
FH Joanneum University of Applied Sciences,Medical University of Vienna
Research period:
2025-01
to 2025-12
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, Nutritional and metabolic system dysfunction, General
The molecular immune signature in ME/CFS as stratification tool for future personalized treatment (IMMUNESTRATIFY)
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Willem A. Dik, Marjan Versnel
Organisations:
Erasmus Medical Center (Erasmus MC),Erasmus University Rotterdam
Research period:
2023-01
to 2027-12
Research types:
Basic research
Research areas:
Immune system dysfunction
The role of the skeletal muscle and myocardial metabolism in ME/CFS: in vivo MRS study.
Project status:
Ongoing
Country:
Austria
Principal investigator:
Martin Krssak
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Treatment courses and determinants in Long COVID and other post-viral symptom complexes (BD-LC-PS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Thomas Grobe
Organisations:
aQua Institute
Research period:
2025-04
to 2028-03
Research types:
Epidemiological research
Research areas:
General
Understanding Potential Infectious Triggers and Mitochondrial Dysfunction in ME/CFS
Project status:
Ongoing
Country:
Latvia
Principal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2025-01
to not available
Research types:
Basic research
Research areas:
Infections, Nutritional and metabolic system dysfunction
Unraveling Endothelial Function in ME/CFS
Project status:
Ongoing
Country:
Austria
Principal investigator:
Francisco Westermeier
Organisations:
FH Joanneum University of Applied Sciences,Warsaw University of Technology,Medical University of Graz
Research period:
Not available
Research types:
Basic research
Research areas:
Cardiovascular system dysfunction
unCOVer Erlangen - ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
Not available
Research types:
Clinical research
Research areas:
Immune system dysfunction

Contact

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