Research projects

Mitochondrial Dysfunction and Metabolic Changes

About

Status:

Ongoing

Principal investigator:

Bhupesh K. Prusty

Country:

Latvia

Study start:

2022-08

Completion (planned):

2025-07

Last update:

2023-12-01

Research types:

Basic research

Research areas:

Immune system dysfunction, Nutritional and metabolic system dysfunction

Interventions:

Not applicable

Priv. Sector Partner:

Not available

Sponsors:

Federal Ministry of Education and Research (BMBF)

Links

Project website

Project description

This project, as part of the Immune Mechanisms of ME (IMMME) research network, will investigate which mechanisms lead to post-infection mitochondrial dysfunction in ME/CFS. The overall aim is to better understand the potential role of infection with herpesviruses in mitochondrial dysfunction in ME/CFS using innovative, interdisciplinary methods in collaboration with the clinical and scientific partners of the IMMME network.

Specifically, the project aims to test antibodies as potential serum-transmissible factors behind persistent mitochondrial dysfunction and a pro-inflammatory state in ME/CFS, and to understand the mechanism of infection-related initiation of mitochondrial dysfunction through the antibodies produced during herpesvirus infection.

(Description adapted from project website: see link above)

Patient cohort

ME/CFS according to Canadian Consensus Criteria (CCC).

Patients enrolled: Not available

Age group: Not available

Research areas

4

Research types

1

Research networks

1

Working groups

1

People

1

Publications

0

Organisations

1

Research areas

Autoimmune disorders are characterised by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. Description adapted from https://www.ncbi.nlm.nih.gov/mesh/68001327 and https://www.ncbi.nlm.nih.gov/mesh/6805670...

Research projects:

Mitochondrial dysfunction

Mitochondrial diseases are conditions caused by abnormal function of the mitochondira. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes. Description adapted from: ...

Research projects:

Immune system dysfunction

Immune system is the body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. Diseases of the immune system are disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-m...

Research projects:

Nutritional and metabolic system dysfunction

A collective term for nutritional disorders resulting from poor absorption or nutritional imbalance, and metabolic disorders resulting from defects in biosynthesis (anabolism) or breakdown (catabolism) of endogenous substances. Description adapted from: https://www.ncbi.nlm.nih.gov/mesh/68009750.

Research projects:

13

Publications:

16