Mitochondrial Dysfunction and Metabolic Changes

Project description

This project, as part of the Immune Mechanisms of ME (IMMME) research network, will investigate which mechanisms lead to post-infection mitochondrial dysfunction in ME/CFS. The overall aim is to better understand the potential role of infection with herpesviruses in mitochondrial dysfunction in ME/CFS using innovative, interdisciplinary methods in collaboration with the clinical and scientific partners of the IMMME network.

Specifically, the project aims to test antibodies as potential serum-transmissible factors behind persistent mitochondrial dysfunction and a pro-inflammatory state in ME/CFS, and to understand the mechanism of infection-related initiation of mitochondrial dysfunction through the antibodies produced during herpesvirus infection.

(Description adapted from project website: see link above)