Immune system dysfunction
Description
Immune system is the body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. Diseases of the immune system are disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both. Description adapted from https://www.ncbi.nlm.nih.gov/mesh/68007154 and https://www.ncbi.nlm.nih.gov/mesh/68007107.
Research projects
36
Research types
17
Research networks
9
Working groups
10
People
122
Publications
51
Event items
3
Research projects
Analysing Antibody Responses against EBV-derived Antigens in ME/CFS
Project status:
CompletedCountry:
Poland, UK, GermanyPrincipal investigator:
Carmen Scheibenbogen, Nuno Sepúlveda
Organisations:
Charité – University Medicine Berlin,Warsaw University of Technology
Research period:
2020-10
to not available
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Antibody repertoires against microbiota as biomarkers for ME/CFS (CFSmicroAbs)
Project status:
OngoingCountry:
NetherlandsPrincipal investigator:
A.P. (Alexandra) Zhernakova
Organisations:
University of Groningen
Research period:
2023-09
to 2027-09
to 2027-09
Research types:
Epidemiological research
Research areas:
Infections, Immune system dysfunction, Digestive system dysfunction, General
Autoantibody-induced Transcriptome and Proteome as Biomarkers
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Gabriela Riemekasten
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Luebeck
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Autoimmunity Risk Variants in the PTPN22 and CTLA4 Genes are Associated with Infectious Onset of ME/CFS
Project status:
CompletedCountry:
GermanyPrincipal investigator:
Sophie Steiner
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction, Genetic risk factors, General
Autoimmunity as a cause of ME/CFS symptoms (AutonoME)
Project status:
OngoingCountry:
NetherlandsPrincipal investigator:
Jeroen den Dunnen
Organisations:
Amsterdam University Medical Center (Amsterdam UMC)
Research period:
2023-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Biosamples, GPCR-Autoantibodies, Data Management and Bioinformatics
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Charité – University Medicine Berlin,University Clinic Schleswig-Holstein (UKSH) - Luebeck,Max Delbrück Center (MDC),Technical University of Munich (TUM)
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, General
Chronic Fatigue Syndrome and Immunedeficiencies
Project status:
CompletedCountry:
AustriaPrincipal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
Medical University of Vienna
Research period:
2019-03
to not available
to not available
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinic and granulocytes
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Alexander Dejaco
Organisations:
University Clinic Regensburg
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Cardiovascular system dysfunction, General
Clinic, HDL proteome, and AI
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Elisabeth Schieffer
Organisations:
University Clinic Giessen and Marburg
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction
Clinical and immunological phenotyping and analysis of EBV autoantigens and autoantigens
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM),Technical University of Munich (TUM)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical and immunological phenotyping, analysis of autoantigens and T and B cell communication
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Birgit Sawitzki
Organisations:
Charité – University Medicine Berlin,Berlin Institute of Health at Charité (BIH)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction
Clinical characterisation for biomarker discovery
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Helena Radbruch
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Converging neurobiological and immune pathways in ME/CFS and post-infectious fatigue syndromes (PIFS)
Project status:
OngoingCountry:
NetherlandsPrincipal investigator:
Ruud Raijmakers
Organisations:
Radboud University Medical Centre (Radboud UMC)
Research period:
2023-01
to 2027-12
to 2027-12
Research types:
Epidemiological research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Endocrine system dysfunction, General
Deciphering systemic and mucosal antibody repertoires against the microbiota in ME/CFS and PCC (CFSabs)
Project status:
OngoingCountry:
AustriaPrincipal investigator:
Thomas Vogl
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
to 2026-03
Research types:
Basic research
Research areas:
Immune system dysfunction, Digestive system dysfunction
Development and analysis of a SARS-CoV-2-induced golden hamster animal model for ME/CFS
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Michael Muehlebach
Organisations:
Paul-Ehrlich-Institute (PEI)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Development and analysis of a SARS-CoV-2-induced mouse model for ME/CFS
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Gregor Ebert
Organisations:
Helmholtz Munich
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction
Development of Diagnostic Tests to Detect Autoantibodies in CFS
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
EBV, SARS-CoV-2, HSV Mimicry Epitopes and Autoantibodies
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Franziska Sotzny
Organisations:
University Hospital rechts der Isar (MRI TUM),Charité – University Medicine Berlin,Technical University of Munich (TUM),Helmholtz Munich
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, General
Establishing Immunological Assays for the Diagnostics of ME/CFS
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Annick Fehrer
Organisations:
Charité – University Medicine Berlin,University Clinic Bonn,German Center for Neurodegenerative Diseases (DZNE)
Research period:
Not available
Research types:
Basic research
Research areas:
Immune system dysfunction
Evaluation of the link between auto-immunity and derangements in immune cell metabolism and function in ME/CFS (EnergiseME)
Project status:
OngoingCountry:
NetherlandsPrincipal investigator:
Niels Eijkelkamp
Organisations:
University Medical Centre Utrecht (UMC Utrecht)
Research period:
2023-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Exploring the Glycome: Identifying Glycosylation-Related Biomarkers for severity stratification in Chronic Fatigue Syndrome
Project status:
OngoingCountry:
AustriaPrincipal investigator:
Davide Ret
Organisations:
Medical University of Vienna,Medical University of Graz,Technical University of Vienna
Research period:
2025-01
to 2025-12
to 2025-12
Research types:
Basic research
Research areas:
Immune system dysfunction
Functional autoantibodies against G-protein-coupled receptors in patients with ME/CFS (FAME)
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Immune system dysfunction
Immune Aberrations in Post-Infectious ME/CFS
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Anna Aschenbrenner
Organisations:
Charité – University Medicine Berlin,University Clinic Bonn,German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction
Immune profiling and blood morphology analyses
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Christian Puta
Organisations:
University Clinic Jena,Friedrich Schiller University Jena
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Clinical research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction, Nervous system dysfunction
Immunoadsorption in Patients With Chronic Fatigue Syndrome Including Patients With Post-COVID-19 CFS (IA-PACS-CFS)
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Harald Pruess
Organisations:
Charité – University Medicine Berlin,German Center for Neurodegenerative Diseases (DZNE)
Research period:
2023-10
to 2025-02
to 2025-02
Research types:
Clinical research
Research areas:
Immune system dysfunction
Immunoadsorption vs Sham Treatment in Post-COVID-19 Patients With Chronic Fatigue Syndrome (EXTINCT post COVID)
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Vega Goedecke
Organisations:
Hannover Medical School (MHH)
Research period:
2023-07
to 2025-06
to 2025-06
Research types:
Clinical research
Research areas:
Immune system dysfunction
Integrative data analyses of human and animal model samples for ME/CFS
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Volker Bruns
Organisations:
Fraunhofer Institute for Integrated Circuits (IIS)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Integrative transcriptome analyses of human and animal model samples for ME/CFS
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Emanuel Wyler
Organisations:
Max Delbrück Center (MDC)
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Nervous system dysfunction, Endocrine system dysfunction, General
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) (PoCoVIT)
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Christiana Franke
Organisations:
Charité – University Medicine Berlin
Research period:
2023-10
to 2025-03
to 2025-03
Research types:
Clinical research
Research areas:
Immune system dysfunction, Nervous system dysfunction
Mitochondrial Dysfunction and Metabolic Changes
Project status:
OngoingCountry:
LatviaPrincipal investigator:
Bhupesh K. Prusty
Organisations:
Riga Stradins University
Research period:
2022-08
to 2025-07
to 2025-07
Research types:
Basic research
Research areas:
Immune system dysfunction, Nutritional and metabolic system dysfunction
Observational Study of the Effect of Immunoadsorption (IA) in Patients < 18 Years of Age with ME/CFS with Evidence of Autoantibodies (BIAKI)
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Wolfgang Ries
Organisations:
DIAKO Hospital
Research period:
2023-11
to 2025-11
to 2025-11
Research types:
Clinical research
Research areas:
Immune system dysfunction
Raman spectroscopic signatures of blood cells
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Anuradha Ramoji
Organisations:
Leibniz Institute of Photonic Technology
Research period:
2024-11
to 2027-11
to 2027-11
Research types:
Basic research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction
Repeat Immunoadsorption Post Covid ME/CFS (RIA)
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2022-08
to 2025-01
to 2025-01
Research types:
Clinical research
Research areas:
Immune system dysfunction
The impact of mast cell activation on epithelial and endothelial barrier dysregulation in post-infectious ME/CFS (DegranulateME)
Project status:
OngoingCountry:
AustriaPrincipal investigator:
Eva Untersmayr-Elsenhuber
Organisations:
FH Joanneum University of Applied Sciences,Medical University of Vienna
Research period:
2025-01
to 2025-12
to 2025-12
Research types:
Basic research
Research areas:
Infections, Immune system dysfunction, Nutritional and metabolic system dysfunction, General
The molecular immune signature in ME/CFS as stratification tool for future personalized treatment (IMMUNESTRATIFY)
Project status:
OngoingCountry:
NetherlandsPrincipal investigator:
Willem A. Dik, Marjan Versnel
Organisations:
Erasmus Medical Center (Erasmus MC),Erasmus University Rotterdam
Research period:
2023-01
to 2027-12
to 2027-12
Research types:
Basic research
Research areas:
Immune system dysfunction
unCOVer Erlangen - ME/CFS
Project status:
OngoingCountry:
GermanyPrincipal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
Not available
Research types:
Clinical research
Research areas:
Immune system dysfunction
Contact
ME/CFS Research Foundation
Ballindamm 27, 20095 Hamburg, Germany
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