Importance of Raman spectroscopic signatures from blood cells in ME/CFS diagnostics

About

Status:

Ongoing

Principal investigator:

Anuradha Ramoji

Country:

Germany

Study start:

Not available

Completion (planned):

Not available

Last update:

2024-06-19

Research types:

Basic research

Research areas:

General

Interventions:

Physical exercise

Priv. Sector Partner:

Not available

Sponsors:

German Association for ME/CFS (DG ME/CFS)

Links

Project website

Project description

The project at the Leibniz Institute for Photonic Technologies under the leadership of Dr. Anuradha Ramoji, in collaboration with the University of Jena, is investigating the possibility of using Raman spectroscopy to identify molecular changes in peripheral blood cells (PBMC) that occur in post-exertional malaise (PEM) in ME/CFS. As part of the study, blood samples from ME/CFS sufferers will be compared with those from people with inflammatory bowel disease. To do this, a whole blood sample is taken from ME/CFS sufferers 24 hours before and after exercise and the blood cells are examined using Raman spectroscopy.

There is currently no biomarker for ME/CFS. The integration of single-cell Raman spectroscopy and artificial intelligence could potentially provide a non-invasive, reliable and objective diagnostic approach for ME/CFS.

(Description adapted from project website: see link above)