Research projects

Biosamples, GPCR-Autoantibodies, Data Management and Bioinformatics

About

Status:

Ongoing

Principal investigator:

Country:

Germany

Study start:

2022-08-01

Completion (planned):

2025-07-31

Last update:

2023-12-01

Research types:

Basic research

Research areas:

Immunological dysfunction, General

Interventions:

Not applicable

Priv. Sector Partner:

Sponsors:

Federal Ministry for Education and Research (BMBF)

Links

Project website

Project description

This project of the Immune Mechanisms of ME (IMMME) research network will provide biospecimens and clinical data from well-established cohorts of patients with post-infectious ME/CFS or autoimmune diseases with overlapping symptoms to ME/CFS, as well as age- and sex-matched healthy controls. The biosamples are made available to the various experimental studies within the IMMME network. Autoantibodies against GPCR are determined using certified ELISA tests (CellTrend). With the help of bioinformatics/biostatistics, clinical and experimental data from the various IMMME projects are linked together in order to identify connections and understand disease mechanisms.

(Description adapted from project website: see link above)

Patient cohort

ME/CFS according to Canadian Consensus Criteria (CCC) compared with autoimmune diseases and healthy controls.

Patients enrolled: Not available

Age group: Not available

Research areas (6)

Research types (2)

Research networks (1)

Working groups (5)

People (7)

Publications (0)

Organisations (4)

Research areas

Autoimmune disorders are characterised by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. (Description adapted from https://www.ncbi.nlm.nih.gov/mesh/68001327 and https://www.ncbi.nlm.nih.gov/mesh/680567...

Research projects:

Immunological dysfunction

Immune system is the body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. Diseases of the immune system are disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-m...

Research projects:

Cross-reactive autoantibodies

Cross-reactivity describes a serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen. Cross-reactive autoantibodies are a form of autoantibodies that bind to a pathogenic structure but also to molecular patterns of the host. (Description adapted from: https://www.ncbi.nlm.nih....

Research projects:

G protein-coupled receptor (GPCR) autoantibodies

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors involved in signal transduction. They share a common structure and signal through heterotrimeric G-Proteins. GPCR-Autoantibodies are functional autoantibodies that bind to GPCR and activate second-messenger cascades in an uncontrolled manner. (Description adapted from:

Research projects:

General research area that is not attributed to a specific organ dysfunction or research entity.

Research projects:

Biobanks are large collections of human biological materials linked to relevant personal and health information, which may include health records, family history, lifestyle and genetic information that are held predominantly for use in health and medical research. (Description adapted from: https://www.ncbi.nlm.nih.gov/pmc/artic...

Research projects: