Research projects

Clinic and granulocytes

About

Status:

Ongoing

Principal investigator:

Alexander Dejaco

Country:

Germany

Study start:

2024-11

Completion (planned):

2027-11

Last update:

2024-11-22

Research types:

Basic research

Research areas:

Immune system dysfunction, Cardiovascular system dysfunction, General

Interventions:

Not applicable

Priv. Sector Partner:

Not available

Sponsors:

Federal Ministry of Education and Research (BMBF)

Links

Project website

Project description

The MIRACLE research newtwork investigates immunological, inflammatory and metabolic signaling pathways of ME/CFS. The long-term goal of this study is to uncover the causes of the disease ME/CFS and to identify clusters and biomarkers that can be used to diagnose and treat ME/CFS.

Within the cooperation between the University Hospital of Marburg (UKGM) and the University Hospital of Regensburg (UKR), a total of 200 patients with ME/CFS and 200 healthy subjects as controls are being examined. The initial data collection and recruitment takes place via a web-based questionnaire and an online video consultation. Patients with very severe ME/CFS who are unable to attend an outpatient appointment are initially offered an online appointment and, if possible, they are visited at home so that this previously rarely considered patient group can also be included. A comprehensive data analysis is carried out using artificial intelligence (AI) and modern statistical methods to search for patterns for biomarkers and patient clusters in the complex data sets.

At the Department of Cardiology, Angiology and Intensive Care Medicine at Marburg University Hospital, the proteome of high-density lipoprotein (HDL) is being investigated, which, as part of reverse cholesterol transport, provides clues to cellular and metabolic processes. In addition, cultured endothelial cells are stimulated with the HDL-associated proteins to investigate their inflammatory potential.

Description adapted from project website: see link above.

Patient cohort

Not available.

Patients enrolled: 400

Age group: Not available

Research areas

7

Research types

1

Research networks

1

Working groups

0

People

1

Publications

0

Organisations

0

Research areas

Endothelial dysfunction

The endothelium maintains an adequate homeostasis via its capacity to produce protective molecules. When this function is lost or damaged, endothelial dysfunction occurs, leading to a reduction in the capacity to maintain homeostasis and the development of pathological inflammatory processes and vascular disease.

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A pathological process characterised by injury or destruction of tissues caused by a variety of cytologic and chemical reactions.

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Immune system dysfunction

Diseases of the immune system are disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.

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Cardiovascular system dysfunction

Cardiovascular diseases describe pathological conditions involving the cardiovascular system, including the heart, blood vessels or the pericardium.

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General research that is not limited to a specific organ or body system dysfunction.

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The systematic study of the complete complement of proteins (proteome) of organisms.

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Vascular dysfunction

Vascular dysfunction, which includes endothelial dysfunction, microvascular dysfunction, and stiffening of large arteries, results when the homeostatic function of relaxation and contraction of blood vessels is affected.

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