Explaining skeletal muscle-related symptoms in patients with ME/CFS: from skeletal muscle to exercise immunology (MuscleME)

Project description

The MuscleME project aims to better understand the pathophysiology of muscle pain, fatigue and worsening of symptoms after exercise (post-exertional malaise) in patients with ME/CFS. For this purpose, blood and muscle biopsies from patients and other individuals from the Netherlands ME/CFS Cohort and Biobank (NMCB) consortium will be analysed for structural and functional alterations. In addition, the mechanism underlying post-exertional malaise (PEM) and the relationship between autoimmunity and muscle adaptations will be investigated. Biomarker clusters are being developed for better diagnostics, treatment and improved patient care.

Goal

This project aims to map ME/CFS patients based on skeletal muscle and circulatory phenotypes. It will also assess the changes in blood  and skeletal muscle in patients with Long COVID and ME/CFS before and after onset of PEM. Furthermore, the study aims to clarify the physiological link between autoimmunity, microclots and skeletal muscle structure and function. The knowledge acquired though this project may improve the diagnosis and treatment of ME/CFS.

Approach

For this study, blood samples and muscle biopsies from patients and other individuals from the Netherlands ME/CFS Cohort and Biobank (NMCB) will be analysed for structural and functional changes. Patients with Long COVID are also included in this study, because infection could underlie ME/CFS, as seen with COVID-19. In addition, the cause of PEM and the relationship between autoimmunity and muscle adaptations will be investigated. Biomarker clusters are being developed with the aim of improving diagnosis, treatment and patient care. Two PhD students are working on this project, together with several international scientists.

(Description adapted from project website: see link above)