Gastroenterology and Nutrition (GNU)

Description

The research group of gastroenterology and nutrition focuses on inflammation, dysbiotic, nutritional, and metabolic disorders of the gastrointestinal tract. The group combines basic science with clinical knowledge to optimise the use of current treatment options in an effort to build an algorithm for personalised treatment and search for new therapeutic targets. The group's projects focus, among others, on a variety of disorders like irritable bowel syndrome, ME/CFS, obesity and Bechterev's disease. More projects are in the pipeline for indications like inflammatory bowel disease and Alzheimers disease. The group has established a general biobank for dysbiosis related disorders for collecting samples of faeces, urine, and blood in the clinical projects. The biobank has a connected registry for clinical information and analysis results related to the samples in the biobank. Planned analyses for the projects include thorough genetic analysis of the gut flora (metagenomic shotgun sequencing), measuring the function of the flora (metabolic profiling) of faecal samples, and leaky gut markers in blood and urine before and after faecal transplantation. Shifts in these measures can be compared to patient reported effects of the faecal transplantation. Description adapted from working group website: see link above.