Lymphoma Biology Group

Description

The group's main focus is translational studies in B-cell lymphoma, a malignancy that arise in B-lymphocytes of the adaptive immune system. The group characterises mutational and genomic alterations to identify events associated with poor outcome, and map tumor clonal evolution patterns. A key interest is also studies of immunosuppression in the tumor microenvironment (TME). Different forms of immunotherapy are becoming cornerstones in treatment of cancer, but novel therapeutic strategies need to overcome the multitude of immune escape mechanisms operating in TME. To identify key immunosuppressive elements, the group characterises patient biopsies using single-cell sequencing, high-dimensional fluorescent flow- and mass cytometry and mass cytometry imaging technologies. Description adapted from working group website: see link above.