Cell Signaling and Cell Death

Description

The group's research is focused on the characterisation of host-pathogen interactions and the role of cell signaling and cell death during intracellular infections to identify novel host and virulence factors that manipulate the host to facilitate infection. Analysis and understanding of involved signaling pathways and factors allow them to identify novel potent therapeutic targets and strategies to fight infections. The group aims to identify and design small molecule compounds that inhibit or eliminate these factors to support the control of infection, including chronic hepatitis B, SARS-CoV-2 and bunyavirus infection. Their work intersects with the fields of molecular virology, cell signaling, immunology and biochemistry and includes in vitro based cell culture assays and tools as well as in vivo infection models in BSL2 and BSL3 laboratories. (Description adapted from working group website: see link above)