Biochemistry and Systems Biology of Metabolism

Description

For a long time, metabolism has been seen as a static series of biochemical reactions. Cellular metabolism is indeed however highly dynamic and adapts to various biological situations, such as ever changing environments, cellular aging or proliferation. These properties draw our attention to the metabolic network, for example, when thinking of ways to develop therapies against cancer and neurodegenerative disorders or understanding the aging process. The group's reserach is focused on: A) Regulatory functions of the metabolic network B) Maintenance of its dynamics C) Systematic identification of gene-metabolism interactions D) Cooperation of cells to share metabolites E) Evolution of metabolism F) Development of high-throughput metabolomic and proteomic methods. (Description adapted from working group website: see link above)