Substrate Metabolism

Description

During the recent years the group has performed studies on glucose metabolism in normal volunteers and diabetic subjects using NMR spectroscopy (non-invasive determination of glycogen concentrations in skeletal muscle and liver, muscular glucose-6-phosphate, and intracellular lipids). The group also applies various tracer techniques and biopsies of skeletal muscle in combination with hyperinsulinemic- and pancreatic-clamp tests to determine rates of glucose turnover, gluconeogenesis, and molecular mechanisms insulin resistance. They are especially interested in elucidating the mechanisms of nutrient induced insulin resistance in humans. A major focus of their research work has been the pathogenesis of vascular and myocardial disease associated with the insulin resistance syndrome and type 2 diabetes. (Description adapted from working group website: see link above)