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Research types

Clinical research

Description

Clinical research includes both interventional (experimental) and observational (non-interventional) studies. A control group is included in most clinical studies. This group receives another treatment regimen and/or placebo, i.e. a therapy without substantial efficacy. Clinical studies should ideally include randomization, in which the patients are allocated by chance to the therapy arms. Description adapted from: https://www.aerzteblatt.de/int/archive/article/64227.

Research projects
32
Research areas
52
Research networks
6
Working groups
29
People
91
Publications
71
Event items
1

Research projects

Immunoadsorption in Patients With Chronic Fatigue Syndrome Including Patients With Post-COVID-19 CFS (IA-PACS-CFS)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Harald Pruess
Organisations:
Charité – University Medicine Berlin, German Center for Neurodegenerative Diseases (DZNE)
Research period:
2023-10
to 2025-02
Research types:
Clinical research
Research areas:
Immune system dysfunction
Immunoadsorption vs Sham Treatment in Post-COVID-19 Patients With Chronic Fatigue Syndrome (EXTINCT post COVID)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Vega Goedecke
Organisations:
Hannover Medical School (MHH)
Research period:
2023-07
to 2025-06
Research types:
Clinical research
Research areas:
Immune system dysfunction
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) (PoCoVIT)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christiana Franke
Organisations:
Charité – University Medicine Berlin
Research period:
2023-10
to 2025-03
Research types:
Clinical research
Research areas:
Immune system dysfunction, Nervous system dysfunction
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome (VERI-LONG)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Judith Bellmann-Strobl
Organisations:
Charité – University Medicine Berlin, Max Delbrück Center (MDC)
Research period:
2023-06
to 2025-04
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Characterisation of brain function and vascular pathology with a focus on autonomic dysfunctions during sleep
Project status:
Ongoing
Country:
Germany
Principal investigator:
Robert Goeder
Organisations:
University Clinic Schleswig-Holstein (UKSH) - Kiel
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Clinical characterisation, integrative morphological and functional studies of organ perfusion and biomarkers in patients with ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Wolfram Doehner
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Musculoskeletal system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Endothelial Dysfunction and Altered Endothelial Biomarkers in Patients with Post-COVID-19 Syndrome and Chronic Fatigue Syndrome (ME/CFS)
Project status:
Completed
Country:
Germany
Principal investigator:
Milan Haffke
Organisations:
Charité – University Medicine Berlin, Max Delbrück Center (MDC), Berlin Institute of Health at Charité (BIH)
Research period:
Not available
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Endothelial Peripheral Arterial Tonometry (EndoPAT)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin, Berlin School of Mind and Brain
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Evaluation of retinal vascular analysis as a diagnostic marker in post-infectious ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christoph Schmaderer
Organisations:
University Hospital rechts der Isar (MRI TUM)
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Functional autoantibodies against G-protein-coupled receptors in patients with ME/CFS (FAME)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Immune system dysfunction
Handgrip strength as a marker for muscular fatigue and fatigability in ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Bianka Jaekel
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
Not available
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction
Harmonisation and standardisation of the diagnosis of PEM in ME/CFS patients
Project status:
Ongoing
Country:
Germany
Principal investigator:
Uta Behrends
Organisations:
University Hospital rechts der Isar (MRI TUM), Technical University of Munich (TUM)
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
General
Harmonised clinical phenotyping and biological signatures
Project status:
Ongoing
Country:
Germany
Principal investigator:
Martina Seifert
Organisations:
Charité – University Medicine Berlin
Research period:
2024-11
to 2027-11
Research types:
Basic research, Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction, General
Immune profiling and blood morphology analyses
Project status:
Ongoing
Country:
Germany
Principal investigator:
Christian Puta
Organisations:
University Clinic Jena, Friedrich Schiller University Jena
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Immune system dysfunction, Musculoskeletal system dysfunction, Nervous system dysfunction
Investigating Cerebral Oxygen Metabolism Dysfunction as a pathomechanism of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Project status:
Ongoing
Country:
Austria
Principal investigator:
Lucas Haider
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-02
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Mobile sleep studies in adolescents
Project status:
Ongoing
Country:
Germany
Principal investigator:
Insa Wolf
Organisations:
Fraunhofer Institute for Digital Media Technology (IDMT)
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Multimodal characterisation of brain function and blood flow, neuronal metabolism and genetic risk structure
Project status:
Ongoing
Country:
Germany
Principal investigator:
Claudia Schilling
Organisations:
Central Institute of Mental Health (CIMH)
Research period:
2024-11
to 2027-11
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Optical Coherence Tomography Angiography (OCT-A) and Non-invasive Dynamic Vessel Analysis (DVA)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin, Berlin School of Mind and Brain, Max Delbrück Center (MDC)
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
Cardiovascular system dysfunction
Skeletal Muscle Structure and Function in Relation to Post-exertional Malaise in Patients With PASC and ME/CFS
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
Michele van Vugt
Organisations:
Amsterdam University Medical Center (Amsterdam UMC)
Research period:
2022-01
to 2025-12
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction
Sodium Content in Lower Leg Muscle in Patients with ME/CFS
Project status:
Completed
Country:
Germany
Principal investigator:
Elisabeth Petter
Organisations:
Charité – University Medicine Berlin
Research period:
Not available
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction, Nutritional and metabolic system dysfunction
Structural and Functional MRI Studies and Accompanying Arterial Spin Labeling (ASL)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carsten Finke
Organisations:
Charité – University Medicine Berlin, Berlin School of Mind and Brain, Max Delbrück Center (MDC)
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
The role of the skeletal muscle and myocardial metabolism in ME/CFS: in vivo MRS study.
Project status:
Ongoing
Country:
Austria
Principal investigator:
Martin Krssak
Organisations:
Medical University of Vienna
Research period:
2025-01
to 2026-03
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Analysis of Blood Immune Cell Transcriptomes by Single-Cell RNA Sequencing (scRNA-seq)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Anna Aschenbrenner
Organisations:
Charité – University Medicine Berlin, University Clinic Bonn, German Center for Neurodegenerative Diseases (DZNE)
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
Hemic and lymphatic system dysfunction, General
Analysis of Differences in Plasma Proteins Using Mass Spectrometry
Project status:
Ongoing
Country:
Germany
Principal investigator:
Markus Ralser
Organisations:
Charité – University Medicine Berlin
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
General
Analysis of Serum/Plasma Markers and Changes in Cellular Composition and Activation of Blood Cells
Project status:
Ongoing
Country:
Germany
Principal investigator:
Birgit Sawitzki
Organisations:
Charité – University Medicine Berlin, Berlin Institute of Health at Charité (BIH)
Research period:
2022-10
to not available
Research types:
Clinical research
Research areas:
General
Post-exertional malaise: a starting point to study and understand ME/CFS
Project status:
Ongoing
Country:
Netherlands
Principal investigator:
C.A.T. (Inge) Zijdewind
Organisations:
University of Groningen
Research period:
2023-01
to 2027-12
Research types:
Clinical research
Research areas:
Musculoskeletal system dysfunction, Nervous system dysfunction, Nutritional and metabolic system dysfunction, Cardiovascular system dysfunction
Application of Direct Current Transcranial Stimulation, Remotely Supervised in Chronic Fatigue (ACTIVATE)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Berthold Langguth
Organisations:
University of Regensburg
Research period:
2023-03
to 2025-01
Research types:
Clinical research
Research areas:
Nervous system dysfunction
Effectiveness of Acceptance Commitment Therapy or Micro Breaks in Patients With CFS/ME
Project status:
Ongoing
Country:
Switzerland
Principal investigator:
Sarah Schiebler
Organisations:
University Hospital Zurich (USZ)
Research period:
2023-08
to 2026-07
Research types:
Clinical research
Research areas:
General, Mental health
Hyperbaric High Pressure Oxygen Therapy (HBOT) in Post-COVID Syndrome and ME/​CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2023-07
to 2025-08
Research types:
Clinical research
Research areas:
Nervous system dysfunction, Cardiovascular system dysfunction
Observational Study of the Effect of Immunoadsorption (IA) in Patients < 18 Years of Age with ME/CFS with Evidence of Autoantibodies (BIAKI)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Wolfgang Ries
Organisations:
DIAKO Hospital
Research period:
2023-11
to 2025-11
Research types:
Clinical research
Research areas:
Immune system dysfunction
Repeat Immunoadsorption Post Covid ME/​CFS (RIA)
Project status:
Ongoing
Country:
Germany
Principal investigator:
Carmen Scheibenbogen
Organisations:
Charité – University Medicine Berlin
Research period:
2022-08
to 2025-01
Research types:
Clinical research
Research areas:
Immune system dysfunction
unCOVer Erlangen - ME/CFS
Project status:
Ongoing
Country:
Germany
Principal investigator:
Bettina Hohberger
Organisations:
University Clinic Erlangen
Research period:
Not available
Research types:
Clinical research
Research areas:
Immune system dysfunction

Contact

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researchregister@mecfs-research.org

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