Regulatory Autoantibodies

Description

For the first time, regulatory autoantibodies were discovered in patients with rheumatic diseases and in healthy subjects, which modulate so-called G protein-coupled receptors (GPCR) and can thus influence many processes such as inflammatory processes. The group conducts research on these functional antibodies in order to uncover mechanisms of inflammatory vascular processes and to develop new therapies. Since 2016, the group's clinic has held an international specialist symposium on regulatory autoantibodies against GPCR every 2 years. In order to answer important questions about the pathogenesis of sclerosis, the group also investigates the importance of extracellular vesicles, which play an obligatory role in the immunoregulatory control of inflammation, vasculopathy and fibrosis. (Description adapted from working group website: see link above)